One-pot Synthesis of Isoxazolines Using Soluble Polymer-supported Acrylates

被引：0
|
作者：
Lan TAO
机构：
来源：
Chinese Chemical Letters | 2005年 / 04期
关键词：
Isoxazolines; 1; 3-dipolar cycloaddition; soluble polymer; liquid-phase synthesis; polythylene glycol;
D O I：
暂无
中图分类号：
O631.3 [高聚物的化学性质];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported. The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in the presence of chloramine-T in methanol gave the corresponding PEG-supported isoxazolines, which can be cleaved from the support under mild condition to afford isoxazolines in good yields (>80%) and high purities (>86%).
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页码：440 / 442
页数：3
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