Effects of sex hormones on apoptosis in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

被引：0
|
作者：
刘超
周辉
瞿锐
刘稚然
机构：
[1] 湖北郧阳医学院附属太和医院皮肤科!十堰442000
[2] 湖南医科大学附属湘雅医院皮肤科!长沙410008
来源：
中华医学杂志(英文版) | 2001年 / 03期
关键词：
系统性红斑狼疮; 性激素; 外周血单一核细胞; 凋亡;
D O I：
暂无
中图分类号：
R593.241 [];
学科分类号：
1002 ; 100201 ;
摘要：
目的　研究脱氢表雄酮 (DHEA)和 (或 )雌二醇 (E2 )对系统性红斑狼疮 (SLE)患者外周血单一核细胞 (PBMC)凋亡的影响及意义。方法　应用吖啶橙 (AO)染色法检测SLE患者、健康献血员PBMC与生理、病理浓度的DHEA和 (或 )E2 培养 4 8h的凋亡百分率。结果　SLE患者PBMC凋亡率高于健康献血员 (P <0 0 1)。不论生理或者病理浓度的E2 对SLE患者、健康献血员PBMC凋亡无影响 (P >0 0 5)。生理浓度的DHEA及DHEA +E2 对健康献血员的PBMC凋亡无影响 (P >0 0 5) ,但可显著抑制SLE患者PBMC凋亡 (P <0 0 5) ;病理浓度的DHEA及DHEA +E2 可显著促进SLE患者、健康献血员的PBMC凋亡 (P <0 0 5)。DHEA及DHEA +E2 对PBMC凋亡的影响 ,两者间无显著差异 (P <0 0 5)。结论　DHEA对SLE患者PBMC凋亡起重要作用 ;DHEA浓度降低可能导致凋亡加快
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页码：67 / 69+108
页数：4
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