Expression of NF-κ B and osteopontin of synovial fluid of patients with knee osteoarthritis

被引：0

作者：

Li-Feng Qin ^{[1
]}

Wan-Chun Wang ^{[1
]}

Han Fang ^{[2
]}

Xin-Zhan Mao ^{[1
]}

Guo-Liang Huang ^{[1
]}

You Chen ^{[1
]}

Hou-De Zhou ^{[3
]}

Yi Shen ^{[1
]}

Li-Hua Qin ^{[4
]}

Dan Peng ^{[1
]}

机构：

[1] Department of Orthopedics,Second Xiang-Ya Hospital,Central South University

[2] Department of Cardiovascular Disease,Xiang-Ya Hospital Central South University

[3] Department of Endocrinology,Second Xiang-Ya Hospital,Central South University

[4] Department of Gynecology,Nursing School of Hunan University of Chinese Medicine

来源：

Asian Pacific Journal of Tropical Medicine | 2013年 / 05期

关键词：

Osteoarthritis; Osteopontin; Synovial fluid;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

1002 ; 100210 ;

摘要：

Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin(OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures,and analyze the relationship between the expressiones of them.Results:OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group, the result showed statistical significance(P<0.05).There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).Conclusions:The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.

引用

页码：379 / 382

页数：4

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