Expression of NF-κ B and osteopontin of synovial fluid of patients with knee osteoarthritis

被引：0

作者：

Li-Feng Qin ^{[1
]}

Wan-Chun Wang ^{[1
]}

Han Fang ^{[2
]}

Xin-Zhan Mao ^{[1
]}

Guo-Liang Huang ^{[1
]}

You Chen ^{[1
]}

Hou-De Zhou ^{[3
]}

Yi Shen ^{[1
]}

Li-Hua Qin ^{[4
]}

Dan Peng ^{[1
]}

机构：

[1] Department of Orthopedics,Second Xiang-Ya Hospital,Central South University

[2] Department of Cardiovascular Disease,Xiang-Ya Hospital Central South University

[3] Department of Endocrinology,Second Xiang-Ya Hospital,Central South University

[4] Department of Gynecology,Nursing School of Hunan University of Chinese Medicine

来源：

Asian Pacific Journal of Tropical Medicine | 2013年 / 05期

关键词：

Osteoarthritis; Osteopontin; Synovial fluid;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

1002 ; 100210 ;

摘要：

Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin(OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures,and analyze the relationship between the expressiones of them.Results:OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group, the result showed statistical significance(P<0.05).There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).Conclusions:The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.

引用

页码：379 / 382

页数：4

共 50 条

[31] The Elevated Expression of Osteopontin and NF-κB in Human Aortic Aneurysms and Its Implication
糜涛
聂斌
张存泰
周洪莲
Current Medical Science, 2011, (05) : 602 - 607
[32] The elevated expression of osteopontin and NF-κB in human aortic aneurysms and its implication
Tao Mi
Bin Nie
Cuntai Zhang
Honglian Zhou
Journal of Huazhong University of Science and Technology [Medical Sciences], 2011, 31 : 602 - 607
[33] Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis
Lei Wang
Li Zhang
Haobo Pan
Songlin Peng
Minmin Lv
William Weijia Lu
BMC Musculoskeletal Disorders, 15
[34] BIOMARKERS OF COMPLEMENT ACTIVATION IN SYNOVIAL FLUID FROM PATIENTS WITH KNEE INJURIES AND OSTEOARTHRITIS
Struglics, A.
Okroj, M.
Blom, A.
Saxne, T.
Lohmander, L. S.
OSTEOARTHRITIS AND CARTILAGE, 2016, 24 : S321 - S323
[35] Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis
Wang, Lei
Zhang, Li
Pan, Haobo
Peng, Songlin
Lv, Minmin
Lu, William Weijia
BMC MUSCULOSKELETAL DISORDERS, 2014, 15
[36] LEVELS OF KERATAN SULFATE IN THE SERUM AND SYNOVIAL-FLUID OF PATIENTS WITH OSTEOARTHRITIS OF THE KNEE
CAMPION, GV
MCCRAE, F
SCHNITZER, TJ
LENZ, ME
DIEPPE, PA
THONAR, EJMA
ARTHRITIS AND RHEUMATISM, 1991, 34 (10): : 1254 - 1259
[37] Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis
Kalogera, Stefania
Jansen, Mylene P.
Bay-Jensen, Anne-Christine
Frederiksen, Peder
Karsdal, Morten A.
Thudium, Christian S.
Mastbergen, Simon C.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (11)
[38] Assesment of Synovial Fluid pH in Osteoarthritis of the HIP and Knee
Roman, Mihai Dan
Fleaca, Radu Sorin
Boicean, Adrian
Bratu, Dan
Birlutiu, Victoria
Rus, Luca Liviu
Tantar, Cristian
Mitariu, Sebastian Ioan Cernusca
REVISTA DE CHIMIE, 2017, 68 (06): : 1242 - 1244
[39] Cartilage markers in synovial fluid in symptomatic knee osteoarthritis
Petersson, IF
Sandqvist, L
Svensson, B
Saxne, T
ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (01) : 64 - 67
[40] CXCL8 and CCL5 Expression in Synovial Fluid and Blood Serum in Patients with Osteoarthritis of the Knee
Adam W. Pierzchala
Damian J. Kusz
Grzegorz Hajduk
Archivum Immunologiae et Therapiae Experimentalis, 2011, 59 : 151 - 155

← 1 2 3 4 5 →