SRBC immunization induces Fos protein expression in rat brain

被引：0
|
作者：
WANG Ling
机构：
来源：
Acta Pharmacologica Sinica | 1999年 / 05期
关键词：
Fos; SRBC immunization induces Fos protein expression in rat brain;
D O I：
暂无
中图分类号：
R741 [神经病学];
学科分类号：
1002 ;
摘要：
It has been reported that centrally or peripherally administered pro-inflammatory cytokines induce the expression of Fos in the central nervous system.However, little is known about the effects of antigen-induced immune response on the expression of immediate early gene in the brain. In the present study, using Fos protein as a marker of activated neurons, we first investigated the functional circuitry in the brain of xeogenitic antigen-challenged rats. Four days following ip immunization with 5× 10~9 sheep red blood cells (SRBC), a specific antibody to SRBC in blood was detected with plaque-forming cell assay (PFC), and a robust and widespread induction of Fos in the brain was
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页码：96 / 96
页数：1
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