MK-801 INDUCES C-FOS PROTEIN IN THALAMIC AND NEOCORTICAL NEURONS OF RAT-BRAIN

被引：80
|
作者：
DRAGUNOW, M
FAULL, RLM
机构：
[1] Department of Anatomy, School of Medicine, University of Auckland, Auckland
来源：
NEUROSCIENCE LETTERS | 1990年 / 111卷 / 1-2期
关键词：
C-fos protein; MK-801; Neocortex; Rat; Thalamus;
D O I：
10.1016/0304-3940(90)90341-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
MK-801, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK-801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK-801 is unclear; however, the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site. © 1990.
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页码：39 / 45
页数：7
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