S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics

被引：0

作者：

Dimitrios Tsikas ^{[1
]}

Erik Hanff ^{[1
]}

Alexander Bollenbach ^{[1
]}

机构：

[1] Core Unit Proteomics, Hannover Medical School

来源：

World Journal of Gastroenterology | 2017年 / 40期

关键词：

S-Adenosyl-L-methionine; Bioavailability; Concentration; Liver;

D O I：

暂无

中图分类号：

R373 [人体病毒学（致病病毒）];

学科分类号：

100103 ; 100705 ;

摘要：

S-Adenosyl-L-methionine(SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.

引用

页码：7343 / 7346

页数：4

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