S-Adenosyl-L-methionine:hydroxide adenosyltransferase:: A SAM enzyme

被引：22
|
作者：
Deng, Hai [1 ]
Botting, Catherine H. [1 ]
Hamilton, John T. G. [2 ]
Russell, Rupert J. M. [1 ]
O'Hagan, David [1 ]
机构：
[1] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[2] Agri Food Biosci Inst, Agr Food & Environm Sci Div, Food Chem Branch, Belfast BT9 5PX, Antrim, North Ireland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 29期
基金：
英国生物技术与生命科学研究理事会;
关键词：
archaea; enzyme catalysis; fluorinase; nucleophilic substitution; SAM enzymes;
D O I：
10.1002/anie.200800794
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Not so DUF: A DUF62 enzyme from the archaeon Pyrococcus horikoshii OT3 converts S-adenosyl-L-methionine (SAM) into adenosine through the nucleophilic attack of a hydroxide ion derived from water (see picture of the active site). The highly conserved nature of Asp68, Arg75, and His127 throughout the DUF62 protein superfamily suggests the wide-spread distribution of this novel catalytic activity in microorganisms. DUF = domain of unknown function. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5357 / 5361
页数：5
相关论文
共 50 条
  • [1] Overexpression of methionine adenosyltransferase in Corynebacterium glutamicum for production of S-adenosyl-l-methionine
    Han, Guoqiang
    Hu, Xiaoqing
    Wang, Xiaoyuan
    [J]. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2016, 63 (05) : 679 - 689
  • [2] Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme
    Shaveta, Goyal
    Shi, Jiahai
    Chow, Vincent T. K.
    Song, Jianxing
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (03) : 1390 - 1395
  • [3] Radical S-Adenosyl-L-Methionine (SAM) Enzyme Involved in the Maturation of the Nitrogenase Cluster
    Rettberg, Lee
    Tanifuji, Kazuki
    Jasniewski, Andrew
    Ribbe, Markus Walter
    Hu, Yilin
    [J]. RADICAL SAM ENZYMES, 2018, 606 : 341 - 361
  • [4] S-adenosyl-L-methionine (SAM) activates RyR2
    Balog, Edward M.
    Kampfer, Angela
    [J]. BIOPHYSICAL JOURNAL, 2007, : 260A - 261A
  • [5] S-ADENOSYL-L-METHIONINE IN A NEUROBLASTOMA
    LYON, GM
    [J]. PEDIATRIC RESEARCH, 1970, 4 (05) : 454 - &
  • [6] Characterization of a S-adenosyl-L-methionine (SAM)-accumulating strain of Scheffersomyces stipitis
    Krizanovic, Stela
    Butorac, Ana
    Mrvcic, Jasna
    Krpan, Maja
    Cindric, Mario
    Bacun-Druzina, Visnja
    Stanzer, Damir
    [J]. INTERNATIONAL MICROBIOLOGY, 2015, 18 (02) : 117 - 125
  • [7] NEUROPHARMACOLOGY OF S-ADENOSYL-L-METHIONINE
    BALDESSARINI, RJ
    [J]. AMERICAN JOURNAL OF MEDICINE, 1987, 83 (5A): : 95 - 103
  • [8] S-ADENOSYL-L-METHIONINE AND THE LIVER
    ORTIZ, P
    MORENO, J
    PUERTA, JL
    MATO, JM
    [J]. ITALIAN JOURNAL OF GASTROENTEROLOGY, 1993, 25 (03): : 135 - 137
  • [9] DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris
    Hu, Hui
    Qian, Jiangchao
    Chu, Ju
    Wang, Yong
    Zhuang, Yingping
    Zhang, Siliang
    [J]. JOURNAL OF BIOTECHNOLOGY, 2009, 141 (3-4) : 97 - 103
  • [10] Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL
    Ding, Wei
    Ji, Xinjian
    Li, Yongzhen
    Zhang, Qi
    [J]. FRONTIERS IN CHEMISTRY, 2016, 4
12345