A novel strategy for addressing post-surgical abdominal adhesions: Janus hydrogel

被引：0
|
作者：
Zhu, Xinhui [1 ]
Zhang, Lipeng [1 ]
Qi, Yingcheng [1 ]
Zhang, Jingyu [1 ]
Tang, Fuxin [1 ,2 ,3 ,4 ]
Zong, Zhen [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Gastrointestinal Surg, 1 MinDe Rd, Nanchang 330006, Jiangxi, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gen Surg Hernia & Abdominal Wall Surg, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Dis, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat sen Univ, Affiliated Hosp 6, Biomed Innovat Ctr, Guangzhou, Guangdong, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2025年 / 249卷
基金：
中国博士后科学基金;
关键词：
Janus hydrogel; Abdominal adhesions; Mechanism of action; Preparation method; Form of application; INJECTABLE HYDROGELS; PREVENTION; SURGERY; INTERCEED; MICROGELS; MEMBRANE; BARRIERS; OPTIONS;
D O I：
10.1016/j.colsurfb.2025.114511
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Abdominal adhesions are a frequent complication after abdominal surgery, which can cause significant pain and burden to patients. Despite various treatment options, including surgical intervention and pharmacotherapy, these often fail to consistently and effectively prevent postoperative abdominal adhesions. Janus hydrogel is famous for its asymmetric characteristics, which shows great prospects in the prevention and treatment of abdominal adhesion. This review outlines the preparation methods, mechanisms of action, and key applications of Janus hydrogel in the prevention of postoperative abdominal adhesions. Furthermore, we examine the current limitations of the Janus hydrogel anti-adhesion barrier and explore potential future directions for its development.
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页数：19
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