A novel strategy for addressing post-surgical abdominal adhesions: Janus hydrogel

被引：0
|
作者：
Zhu, Xinhui [1 ]
Zhang, Lipeng [1 ]
Qi, Yingcheng [1 ]
Zhang, Jingyu [1 ]
Tang, Fuxin [1 ,2 ,3 ,4 ]
Zong, Zhen [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Gastrointestinal Surg, 1 MinDe Rd, Nanchang 330006, Jiangxi, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gen Surg Hernia & Abdominal Wall Surg, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Dis, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat sen Univ, Affiliated Hosp 6, Biomed Innovat Ctr, Guangzhou, Guangdong, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2025年 / 249卷
基金：
中国博士后科学基金;
关键词：
Janus hydrogel; Abdominal adhesions; Mechanism of action; Preparation method; Form of application; INJECTABLE HYDROGELS; PREVENTION; SURGERY; INTERCEED; MICROGELS; MEMBRANE; BARRIERS; OPTIONS;
D O I：
10.1016/j.colsurfb.2025.114511
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Abdominal adhesions are a frequent complication after abdominal surgery, which can cause significant pain and burden to patients. Despite various treatment options, including surgical intervention and pharmacotherapy, these often fail to consistently and effectively prevent postoperative abdominal adhesions. Janus hydrogel is famous for its asymmetric characteristics, which shows great prospects in the prevention and treatment of abdominal adhesion. This review outlines the preparation methods, mechanisms of action, and key applications of Janus hydrogel in the prevention of postoperative abdominal adhesions. Furthermore, we examine the current limitations of the Janus hydrogel anti-adhesion barrier and explore potential future directions for its development.
引用
收藏
页数：19
相关论文
共 50 条
  • [31] POST-SURGICAL ADHESIONS ARE CAUSED BY MEMBRANE BRIDGES AND FUSIONS BETWEEN MESOTHELIAL SURFACES
    Fischer, A.
    Koopmans, T.
    Ramesh, P.
    Christ, S.
    Strunz, M.
    Aichler, M.
    Feuchtinger, A.
    Walch, A.
    Ansari, M.
    Theis, F.
    Schorpp, K.
    Hadian, K.
    Neumann, P. -A.
    Schiller, H.
    Rinkevich, Y.
    WOUND REPAIR AND REGENERATION, 2020, 28 (02) : A10 - A10
  • [32] A novel experimental rat model of peripheral nerve scarring that reliably mimics post-surgical complications and recurring adhesions
    Lemke, Angela
    Penzenstadler, Carina
    Ferguson, James
    Lidinsky, Dominika
    Hopf, Rudolf
    Bradl, Monika
    Redl, Heinz
    Wolbank, Susanne
    Hausner, Thomas
    DISEASE MODELS & MECHANISMS, 2017, 10 (08) : 1015 - 1025
  • [33] Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions
    Lv, Houyi
    Wu, Bingbing
    Song, Jianyuan
    Wu, Wei
    Cai, Wangyu
    Xu, Jian
    JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (33) : 6536 - 6552
  • [34] Novel Macromolecular Crosslinking Hydrogel to Reduce Intra-Abdominal Adhesions
    Falabella, Christine A.
    Melendez, Mark M.
    Weng, Lihui
    Chen, Weiliam
    JOURNAL OF SURGICAL RESEARCH, 2010, 159 (02) : 772 - 778
  • [35] POST-SURGICAL ANTERIOR PSEUDOMENINGOCELE PRESENTING AS AN ABDOMINAL-MASS
    KOLAWOLE, TM
    PATEL, PJ
    NAIMURRAHAMAN
    COMPUTERIZED RADIOLOGY, 1987, 11 (5-6): : 237 - 240
  • [36] Surgical management of post-surgical intercostal thoracic-abdominal nerve neuroma
    Raikar, Soubrata
    Patil, Arun Angelo
    Simmons, Amelia
    Nilles-Melchert, Thomas
    EGYPTIAN JOURNAL OF NEUROSURGERY, 2021, 36 (01)
  • [37] A case of lipidogram abnormality on post-surgical abdominal drain fluid
    Hamet, Lya
    Moreau, Lia
    Bendavid, Claude
    Moreau, Caroline
    ANNALES DE BIOLOGIE CLINIQUE, 2023, 81 (03) : 327 - 330
  • [38] Surgical management of post-surgical intercostal thoracic-abdominal nerve neuroma
    Soubrata Raikar
    Arun Angelo Patil
    Amelia Simmons
    Thomas Nilles-Melchert
    Egyptian Journal of Neurosurgery, 36
  • [39] Combination of Sterile Injury and Microbial Contamination to Model Post-surgical Peritoneal Adhesions in Mice
    Bayer, Julia
    Stroka, Deborah
    Kubes, Paul
    Candinas, Daniel
    Zindel, Joel
    BIO-PROTOCOL, 2022, 12 (16):
  • [40] Early Second-Look Hysteroscopy: Prevention and Treatment of Intrauterine Post-surgical Adhesions
    Sebbag, Lauren
    Even, Marc
    Fay, Stephanie
    Naoura, Iptissem
    Revaux, Aurelie
    Carbonnel, Marie
    Pirtea, Paul
    de Ziegler, Dominique
    Ayoubi, Jean-Marc
    FRONTIERS IN SURGERY, 2019, 6
12345