Using oncolytic viruses to induce hyperacute rejection against cancer

被引：0
|
作者：
Kaufman, Howard L. [1 ]
Silk, Ann W. [2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
来源：
NATURE REVIEWS CLINICAL ONCOLOGY | 2025年
关键词：
D O I：
10.1038/s41571-025-01006-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a recently reported study, a novel engineered oncolytic Newcastle disease virus encoding porcine alpha 1,3-galactosyltransferase was evaluated in monkeys with CRISPR-induced primary hepatocellular carcinoma and in a phase I clinical trial. The virus induced hyperacute tumour rejection and an objective response rate of 35% in 20 evaluable patients. This approach highlights the promises and challenges of oncolytic virus drug development.
引用
收藏
页码：309 / 310
页数：2
相关论文
共 50 条
  • [21] Immunotherapy against pancreatic cancer using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M
    Nistal, E.
    Bunuales, M.
    Poutou, J.
    Bravo-Perez, C.
    Carte, B.
    Gonzalez-Aseguinolaza, G.
    Prieto, J.
    Hernandez-Alcoceba, R.
    Larrea, E.
    HUMAN GENE THERAPY, 2014, 25 (11) : A48 - A48
  • [22] Oncolytic Viruses and Their Application to Cancer Immunotherapy
    Chiocca, E. Antonio
    Rabkin, Samuel D.
    CANCER IMMUNOLOGY RESEARCH, 2014, 2 (04) : 295 - 300
  • [23] Oncolytic Viruses in the Treatment of Bladder Cancer
    Potts, Kyle G.
    Hitt, Mary M.
    Moore, Ronald B.
    ADVANCES IN UROLOGY, 2012, 2012
  • [24] Controversy - Fighting cancer with oncolytic viruses
    Chernajovsky, Y
    Layward, L
    Lemoine, N
    BRITISH MEDICAL JOURNAL, 2006, 332 (7534): : 170 - 172
  • [25] Development of oncolytic viruses for cancer therapy
    Abd-Aziz, Noraini
    Poh, Chit Laa
    TRANSLATIONAL RESEARCH, 2021, 237 : 98 - 123
  • [26] The application of oncolytic viruses in cancer therapy
    Yang Gao
    Yan Wu
    Tian Huan
    Xiaoyan Wang
    Jun Xu
    Qinggang Xu
    Feng Yu
    Haifeng Shi
    Biotechnology Letters, 2021, 43 : 1945 - 1954
  • [27] Oncolytic viruses as therapeutic cancer vaccines
    Bartlett, David L.
    Liu, Zuqiang
    Sathaiah, Magesh
    Ravindranathan, Roshni
    Guo, Zongbi
    He, Yukai
    Guo, Zong Sheng
    MOLECULAR CANCER, 2013, 12
  • [28] Oncolytic Viruses in Cancer Treatment A Review
    Lawler, Sean E.
    Speranza, Maria-Carmela
    Cho, Choi-Fong
    Chiocca, E. Antonio
    JAMA ONCOLOGY, 2017, 3 (06) : 841 - 849
  • [29] Oncolytic measles viruses for cancer therapy
    Nakamura, T
    Russell, SJ
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2004, 4 (10) : 1685 - 1692
  • [30] Oncolytic viruses as therapeutic cancer vaccines
    David L Bartlett
    Zuqiang Liu
    Magesh Sathaiah
    Roshni Ravindranathan
    Zongbi Guo
    Yukai He
    Zong Sheng Guo
    Molecular Cancer, 12
12345