Using oncolytic viruses to induce hyperacute rejection against cancer

被引：0
|
作者：
Kaufman, Howard L. [1 ]
Silk, Ann W. [2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
来源：
NATURE REVIEWS CLINICAL ONCOLOGY | 2025年
关键词：
D O I：
10.1038/s41571-025-01006-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a recently reported study, a novel engineered oncolytic Newcastle disease virus encoding porcine alpha 1,3-galactosyltransferase was evaluated in monkeys with CRISPR-induced primary hepatocellular carcinoma and in a phase I clinical trial. The virus induced hyperacute tumour rejection and an objective response rate of 35% in 20 evaluable patients. This approach highlights the promises and challenges of oncolytic virus drug development.
引用
收藏
页码：309 / 310
页数：2
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