CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine-induced CD4+ TRM in the gastric epithelium

被引：0

作者：

Tong, Jinzhe ^{[1
]}

Chen, Simiao ^{[1
]}

Gu, Xinyue ^{[1
]}

Zhang, Xuanqi ^{[1
]}

Wei, Fang ^{[1
]}

Xing, Yingying ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing, Peoples R China

来源：

MUCOSAL IMMUNOLOGY | 2024年 / 17卷 / 05期

关键词：

TGF-BETA; CELLULAR NAD; RECEPTOR; MACROPHAGES; ACTIVATION; AUTOPHAGY; IMMUNITY; CHANNEL; TARGET;

D O I：

10.1016/j.mucimm.2024.06.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue-resident memory T cells (TRM) can be induced by infection and vaccination, and play a key role in maintaining long-term protective immunity against mucosal pathogens. Our studies explored the key factors and mechanisms affecting the differentiation, maturation, and stable residence of gastric epithelial CD4+ TRM induced by Helicobacter pylori (Hp) vaccine and optimized Hp vaccination to promote the generation and residence of TRM. Cluster of differentiation (CD)38 regulated mitochondrial activity and enhanced transforming growth factor-(3 signal transduction to promote the differentiation and residence of gastric epithelial CD4+ TRM by mediating the expression of CD105. Extracellular nucleotides influenced the long-term maintenance of TRM in gastric epithelium by the P2X7 receptor (P2RX7). Vitamin D3 and Gram-positive enhancer matrix (GEM) particles as immune adjuvants combined with Hp vaccination promoted the production of CD69+CD103+CD4+ TRM.

引用

页码：990 / 1004

页数：15

共 45 条

[1] CD38 is methylated in prostate cancer and regulates extracellular NAD+
Jack Mottahedeh
Michael C. Haffner
Tristan R. Grogan
Takao Hashimoto
Preston D. Crowell
Himisha Beltran
Andrea Sboner
Rohan Bareja
David Esopi
William B. Isaacs
Srinivasan Yegnasubramanian
Matthew B. Rettig
David A. Elashoff
Elizabeth A. Platz
Angelo M. De Marzo
Michael A. Teitell
Andrew S. Goldstein
Cancer & Metabolism, 6
[2] CD38 is methylated in prostate cancer and regulates extracellular NAD+
Mottahedeh, Jack
Haffner, Michael C.
Grogan, Tristan R.
Hashimoto, Takao
Crowell, Preston D.
Beltran, Himisha
Sboner, Andrea
Bareja, Rohan
Esopi, David
Isaacs, William B.
Yegnasubramanian, Srinivasan
Rettig, Matthew B.
Elashoff, David A.
Platz, Elizabeth A.
De Marzo, Angelo M.
Teitell, Michael A.
Goldstein, Andrew S.
CANCER & METABOLISM, 2018, 6
[3] The new insight into extracellular NAD+ degradation-the contribution of CD38 and CD73 in calcific aortic valve disease
Jablonska, Patrycja
Kutryb-Zajac, Barbara
Mierzejewska, Paulina
Jasztal, Agnieszka
Bocian, Barbara
Lango, Romuald
Rogowski, Jan
Chlopicki, Stefan
Smolenski, Ryszard T.
Slominska, Ewa M.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (13) : 5884 - 5898
[4] Mechanism of CD38 via NAD+ in the Development of Non-alcoholic Fatty Liver Disease
Dong, Min
Wang, Shuo
Pei, Zuowei
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2023, 20 (02): : 262 - 266
[5] CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Chini, Claudia C. S.
Peclat, Thais R.
Warner, Gina M.
Kashyap, Sonu
Espindola-Netto, Jair Machado
de Oliveira, Guilherme C.
Gomez, Lilian S.
Hogan, Kelly A.
Tarrago, Mariana G.
Puranik, Amrutesh S.
Agorrody, Guillermo
Thompson, Katie L.
Dang, Kevin
Clarke, Starlynn
Childs, Bennett G.
Kanamori, Karina S.
Witte, Micaela A.
Vidal, Paola
Kirkland, Anna L.
De Cecco, Marco
Chellappa, Karthikeyani
McReynolds, Melanie R.
Jankowski, Connor
Tchkonia, Tamara
Kirkland, James L.
Sedivy, John M.
van Deursen, Jan M.
Baker, Darren J.
van Schooten, Wim
Rabinowitz, Joshua D.
Baur, Joseph A.
Chini, Eduardo N.
NATURE METABOLISM, 2020, 2 (11) : 1284 - 1304
[6] CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Claudia C. S. Chini
Thais R. Peclat
Gina M. Warner
Sonu Kashyap
Jair Machado Espindola-Netto
Guilherme C. de Oliveira
Lilian S. Gomez
Kelly A. Hogan
Mariana G. Tarragó
Amrutesh S. Puranik
Guillermo Agorrody
Katie L. Thompson
Kevin Dang
Starlynn Clarke
Bennett G. Childs
Karina S. Kanamori
Micaela A. Witte
Paola Vidal
Anna L. Kirkland
Marco De Cecco
Karthikeyani Chellappa
Melanie R. McReynolds
Connor Jankowski
Tamara Tchkonia
James L. Kirkland
John M. Sedivy
Jan M. van Deursen
Darren J. Baker
Wim van Schooten
Joshua D. Rabinowitz
Joseph A. Baur
Eduardo N. Chini
Nature Metabolism, 2020, 2 : 1284 - 1304
[7] Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+
Roboon, Jureepon
Hattori, Tsuyoshi
Ishii, Hiroshi
Takarada-Iemata, Mika
Nguyen, Dinh Thi
Heer, Collin D.
O'Meally, Denis
Brenner, Charles
Yamamoto, Yasuhiko
Okamoto, Hiroshi
Higashida, Haruhiro
Hori, Osamu
JOURNAL OF NEUROCHEMISTRY, 2021, 158 (02) : 311 - 327
[8] CD38 is present in peripheral nerve terminals and contributes to the removal of neurally released extracellular β-NAD+ in mesenteric blood vessels and urinary bladder
Mutafova-Yambolieva, Violeta N.
Smyth, Lisa M.
Breen, Leanne T.
Yamboliev, Ilia A.
MOLECULAR MEDICINE, 2006, 12 : S17 - S18
[9] The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
Barbosa, Maria Thereza P.
Soares, Sandra M.
Novak, Colleen M.
Sinclair, David
Levine, James A.
Aksoy, Pinar
Chini, Eduardo Nunes
FASEB JOURNAL, 2007, 21 (13): : 3629 - 3639
[10] Vaccine-Induced CD107a+ CD4+ T Cells Are Resistant to Depletion following AIDS Virus Infection
Terahara, Kazutaka
Ishii, Hiroshi
Nomura, Takushi
Takahashi, Naofumi
Takeda, Akiko
Shiino, Teiichiro
Tsunetsugu-Yokota, Yasuko
Matano, Tetsuro
JOURNAL OF VIROLOGY, 2014, 88 (24) : 14232 - 14240

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