CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine-induced CD4+ TRM in the gastric epithelium

被引：0
|
作者：
Tong, Jinzhe [1 ]
Chen, Simiao [1 ]
Gu, Xinyue [1 ]
Zhang, Xuanqi [1 ]
Wei, Fang [1 ]
Xing, Yingying [1 ]
机构：
[1] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing, Peoples R China
来源：
MUCOSAL IMMUNOLOGY | 2024年 / 17卷 / 05期
关键词：
TGF-BETA; CELLULAR NAD; RECEPTOR; MACROPHAGES; ACTIVATION; AUTOPHAGY; IMMUNITY; CHANNEL; TARGET;
D O I：
10.1016/j.mucimm.2024.06.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tissue-resident memory T cells (TRM) can be induced by infection and vaccination, and play a key role in maintaining long-term protective immunity against mucosal pathogens. Our studies explored the key factors and mechanisms affecting the differentiation, maturation, and stable residence of gastric epithelial CD4+ TRM induced by Helicobacter pylori (Hp) vaccine and optimized Hp vaccination to promote the generation and residence of TRM. Cluster of differentiation (CD)38 regulated mitochondrial activity and enhanced transforming growth factor-(3 signal transduction to promote the differentiation and residence of gastric epithelial CD4+ TRM by mediating the expression of CD105. Extracellular nucleotides influenced the long-term maintenance of TRM in gastric epithelium by the P2X7 receptor (P2RX7). Vitamin D3 and Gram-positive enhancer matrix (GEM) particles as immune adjuvants combined with Hp vaccination promoted the production of CD69+CD103+CD4+ TRM.
引用
收藏
页码：990 / 1004
页数：15
相关论文
共 45 条
  • [21] Vaccine-induced inflammation and inflammatory monocytes promote CD4+ T cell-dependent immunity against murine salmonellosis
    Wang, Nancy
    Scott, Timothy A.
    Kupz, Andreas
    Shreenivas, Meghanashree M.
    Peres, Newton G.
    Hocking, Dianna M.
    Yang, Chenying
    Jebeli, Leila
    Beattie, Lynette
    Groom, Joanna R.
    Pierce, Thomas P.
    Wakim, Linda M.
    Bedoui, Sammy
    Strugnell, Richard A.
    PLOS PATHOGENS, 2023, 19 (09)
  • [22] Codonopsis pilosula Polysaccharides Alleviate ABETA1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway
    Hu, Yi R.
    Xing, San L.
    Chen, Chuan
    Shen, Ding Z.
    Chen, Jiu L.
    CURRENT ALZHEIMER RESEARCH, 2021, 18 (03) : 208 - 221
  • [23] CD38 regulate LPS induced acute kidney injury by TLR4-NFκB-IFN-γ signaling pathway
    Li, R.
    Li, Q.
    Wu, C.
    Zhang, H.
    Du, Y.
    Liu, Y.
    Jin, P.
    Song, K.
    Shi, Q.
    Kuang, N.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 52 - 52
  • [24] The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection
    White, Michael T.
    Bejon, Philip
    Olotu, Ally
    Griffin, Jamie T.
    Riley, Eleanor M.
    Kester, Kent E.
    Ockenhouse, Christian F.
    Ghani, Azra C.
    PLOS ONE, 2013, 8 (04):
  • [25] CD4+ SUBSET EXPRESSION IN MURINE CANDIDIASIS - TH RESPONSES CORRELATE DIRECTLY WITH GENETICALLY-DETERMINED SUSCEPTIBILITY OR VACCINE-INDUCED RESISTANCE
    ROMANI, L
    MENCACCI, A
    CENCI, E
    SPACCAPELO, R
    MOSCI, P
    PUCCETTI, P
    BISTONI, F
    JOURNAL OF IMMUNOLOGY, 1993, 150 (03): : 925 - 931
  • [26] HRES-1/Rab4 Controls the Overexpression of CD38 and Depletion of IL-2 in CD4+ T Cells; Potential Involvement in Proinflammatory Lineage Development in SLE
    Park, Seong Hee Joy
    Patel, Akshay
    Perl, Andras
    ARTHRITIS & RHEUMATOLOGY, 2022, 74 : 1327 - 1330
  • [27] Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia
    Kamei, Akinobu
    Wu, Weihui
    Traficante, David C.
    Koh, Andrew Y.
    Van Rooijen, Nico
    Pier, Gerald B.
    Priebe, Gregory P.
    JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (01): : 39 - 49
  • [28] CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection
    Farris, Christina M.
    Morrison, Sandra G.
    Morrison, Richard P.
    INFECTION AND IMMUNITY, 2010, 78 (10) : 4374 - 4383
  • [29] Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4+ T cells
    Podschwadt, Philip
    Malyshkina, Anna
    Windmann, Sonja
    Papadamakis, Athanasios
    Kerkmann, Leonie
    Lapuente, Dennis
    Tenbusch, Matthias
    Lu, Mengji
    Schindler, Michael
    Lang, Karl Sebastian
    Hansen, Wiebke
    Bayer, Wibke
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [30] VACCINE-INDUCED CD4+ T-CELLS AGAINST THE SIMIAN IMMUNODEFICIENCY VIRUS GAG PROTEIN - EPITOPE SPECIFICITY AND RELEVANCE TO PROTECTIVE IMMUNITY
    MILLS, KHG
    BARNARD, AL
    WILLIAMS, M
    PAGE, M
    LING, C
    STOTT, EJ
    SILVERA, P
    TAFFS, F
    KINGSMAN, AS
    ADAMS, SE
    ALMOND, N
    KITCHIN, PA
    JONES, WC
    JOURNAL OF IMMUNOLOGY, 1991, 147 (10): : 3560 - 3567
12345