Synthetic Strategies and Applications of Fluorine-Containing Bridged Bicyclic Compounds

Bridged bicyclic compounds (BBCs) have recently emerged as effective 3D-isosteres of planar aryl and heteroaryl rings. Current synthetic endeavours are devoted to accessing these complex structures bearing functionalities in different positions of the aliphatic rings. Of particular interest is the incorporation of F-containing motifs, since it allows the generation of isosteric units with improved physicochemical properties, including lipophilicity, water solubility, or oxidative resistance.