Synthetic Strategies and Applications of Fluorine-Containing Bridged Bicyclic Compounds

被引：1

作者：

Baldon, Simone ^{[1
]}

Dell'Amico, Luca ^{[1
]}

Cuadros, Sara ^{[1
]}

机构：

[1] Univ Padua, Dept Chem Sci, Via Francesco Marzolo 1, I-35131 Padua, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 43期

基金：

欧洲研究理事会;

关键词：

Fluorinated isosteres; Bicycloalkanes; Bridged bicyclic compounds; Synthetic methods; DESIGN; ROUTE; ACID; PEPTIDE; LABEL;

D O I：

10.1002/ejoc.202400604

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bridged bicyclic compounds (BBCs) have recently emerged as effective 3D-isosteres of planar aryl and heteroaryl rings. Current synthetic endeavours are devoted to accessing these complex structures bearing functionalities in different positions of the aliphatic rings. Of particular interest is the incorporation of F-containing motifs, since it allows the generation of isosteric units with improved physicochemical properties, including lipophilicity, water solubility, or oxidative resistance.

引用

页数：10

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