Target validation and drug discovery efforts on exoribonuclease XRN1

被引：0
|
作者：
Lynes, Maureen M.
Lockbaum, Gordon J.
Sparling, Brian A.
Shen, Sophie A.
Nayak, Sunaina P.
Knockenhauer, Kevin
Grigoriu, Simina
Buker, Shane M.
Duncan, Kenneth W.
Copeland, Robert A.
Blakemore, Stephen J.
Silver, Serena J.
Boriack-Sjodin, P. Ann
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2024年 / 23卷 / 11期
关键词：
D O I：
10.1158/1538-8514.RNADRIVERS24-PR006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PR006
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Synaptic control of mRNA translation by reversible assembly of XRN1 bodies
    Luchelli, Luciana
    Thomas, Maria Gabriela
    Boccaccio, Graciela L.
    JOURNAL OF CELL SCIENCE, 2015, 128 (08) : 1542 - 1554
  • [42] The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
    Bernat Blasco-Moreno
    Leire de Campos-Mata
    René Böttcher
    José García-Martínez
    Jennifer Jungfleisch
    Danny D. Nedialkova
    Shiladitya Chattopadhyay
    María-Eugenia Gas
    Baldomero Oliva
    José E. Pérez-Ortín
    Sebastian A. Leidel
    Mordechai Choder
    Juana Díez
    Nature Communications, 10
  • [43] Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
    Sunny Sharma
    Jun Yang
    Ewa Grudzien-Nogalska
    Jessica Shivas
    Kelvin Y. Kwan
    Megerditch Kiledjian
    Nature Communications, 13
  • [44] The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
    Blasco-Moreno, Bernat
    de Campos-Mata, Leire
    Bottcher, Rene
    Garcia-Martinez, Jose
    Jungfleisch, Jennifer
    Nedialkova, Danny D.
    Chattopadhyay, Shiladitya
    Gas, Maria-Eugenia
    Oliva, Baldomero
    Perez-Ortin, Jose E.
    Leidel, Sebastian A.
    Choder, Mordechai
    Diez, Juana
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [45] Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
    Sharma, Sunny
    Yang, Jun
    Grudzien-Nogalska, Ewa
    Shivas, Jessica
    Kwan, Kelvin Y.
    Kiledjian, Megerditch
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [46] Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome
    Orban, TI
    Izaurralde, E
    RNA, 2005, 11 (04) : 459 - 469
  • [47] Peptide nanotechnology: Applications in target validation and drug discovery
    Woodman, R
    Ferrigno, PK
    BRITISH JOURNAL OF CANCER, 2002, 86 : S118 - S118
  • [48] Target identification and validation in drug discovery: the role of proteomics
    Kopec, KK
    Bozyczko-Coyne, D
    Williams, M
    BIOCHEMICAL PHARMACOLOGY, 2005, 69 (08) : 1133 - 1139
  • [49] Transgenesis in Drug Discovery: Enhancing Target Identification and Validation
    Mete, Rumela
    Das, Sourav
    Saha, Arindam
    Roy, Sukanta
    Mondal, Smritilekha
    Bose, Anirbandeep
    Basu, Biswajit
    Elossaily, Gehan M.
    Prajapati, Bhupendra
    MOLECULAR BIOTECHNOLOGY, 2025,
  • [50] RNA silencing technologies in drug discovery and target validation
    Rayburn, E
    Wang, H
    He, J
    Zhang, RW
    LETTERS IN DRUG DESIGN & DISCOVERY, 2005, 2 (01) : 1 - 18
12345