Target validation and drug discovery efforts on exoribonuclease XRN1

被引:0
|
作者
Lynes, Maureen M.
Lockbaum, Gordon J.
Sparling, Brian A.
Shen, Sophie A.
Nayak, Sunaina P.
Knockenhauer, Kevin
Grigoriu, Simina
Buker, Shane M.
Duncan, Kenneth W.
Copeland, Robert A.
Blakemore, Stephen J.
Silver, Serena J.
Boriack-Sjodin, P. Ann
机构
关键词
D O I
10.1158/1538-8514.RNADRIVERS24-PR006
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PR006
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Regulation of telomere metabolism by the RNA processing protein Xrn1
    Cesena, Daniele
    Cassani, Corinne
    Rizzo, Emanuela
    Lisby, Michael
    Bonetti, Diego
    Longhese, Maria Pia
    NUCLEIC ACIDS RESEARCH, 2017, 45 (07) : 3860 - 3874
  • [32] Dissecting the Roles of the 5′ Exoribonucleases Xrn1 and Xrn2 in Restricting Hepatitis C Virus Replication
    Li, You
    Yamane, Daisuke
    Lemon, Stanley M.
    JOURNAL OF VIROLOGY, 2015, 89 (09) : 4857 - 4865
  • [33] Structure of the 80S ribosome–Xrn1 nuclease complex
    Petr Tesina
    Elisabeth Heckel
    Jingdong Cheng
    Micheline Fromont-Racine
    Robert Buschauer
    Lukas Kater
    Birgitta Beatrix
    Otto Berninghausen
    Alain Jacquier
    Thomas Becker
    Roland Beckmann
    Nature Structural & Molecular Biology, 2019, 26 : 275 - 280
  • [34] Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper
    Waldron, Joseph A.
    Jones, Christopher I.
    Towler, Benjamin P.
    Pashler, Amy L.
    Grima, Dominic P.
    Hebbes, Stephen
    Crossman, Samuel H.
    Zabolotskaya, Maria V.
    Newbury, Sarah F.
    BIOLOGY OPEN, 2015, 4 (05): : 649 - 660
  • [35] Target validation and drug discovery: An overview.
    Kallick, D
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U470 - U470
  • [36] SiRNAs in drug discovery: Target validation and beyond
    Natt, Francois
    CURRENT OPINION IN MOLECULAR THERAPEUTICS, 2007, 9 (03) : 242 - 247
  • [37] The importance of target validation in drug discovery and development
    Lowe, John A.
    Jones, Phil
    Wilson, David M.
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2009, 12 (05) : 581 - 584
  • [38] Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
    Hosseini, Amir
    Lindholm, Havard T.
    Chen, Raymond
    Mehdipour, Parinaz
    Marhon, Sajid A.
    Ishak, Charles A.
    Moore, Paul C.
    Classon, Marie
    Gioacchino, Raymond Andrea Di
    Greenbaum, Benjamin
    Carvalho, Daniel D. De
    CELL REPORTS, 2024, 43 (02):
  • [39] Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
    Ran, Xue-Bin
    Ding, Ling-Wen
    Sun, Qiao-Yang
    Yang, Henry
    Said, Jonathan W.
    Zhentang, Lao
    Madan, Vikas
    Dakle, Pushkar
    Xiao, Jin-Fen
    Loh, Xinyi
    Li, Ying
    Xu, Liang
    Xiang, Xiao-Qiang
    Wang, Ling-Zhi
    Goh, Boon Cher
    Lin, De-Chen
    Chng, Wee Joo
    Tan, Soo-Yong
    Jha, Sudhakar
    Koeffler, H. Phillip
    CANCER RESEARCH, 2023, 83 (06) : 922 - 938
  • [40] XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts
    Rowley, Paul A.
    Ho, Brandon
    Bushong, Sarah
    Johnson, Arlen
    Sawyer, Sara L.
    PLOS PATHOGENS, 2016, 12 (10)