Background: Burdening health and illness issues such as physical or mental illnesses, accidents, disabilities, and life eventssuch as birth or death influence the health and functioning of families and contribute to the complexity of care and health carecosts. Considerable research has confirmed the benefits of a family systems-centered care approach for patients, family caregivers,families, and health care professionals. However, health care professionals face barriers in working with families, such as feelingunprepared. Family systems-centered therapeutic conversations support families'day-to-day coping, resilience, and health. Afamily systems care unit (FSCU) was recently established as a real-life laboratory at one of the Swiss Universities of AppliedSciences. In this unit, health care professionals offer therapeutic conversations to families and individual family members tosupport daily symptom management and functioning, soften suffering, and increase health and well-being. These conversationsare observed in real time through a 1-way window by other health care professionals, students, and trainees and are recorded withvideo for research and education. Little is known about how therapeutic conversations contribute to meaningful changes inburdened families and the benefits of vicarious learning in a real-life laboratory setting for family systems care.Objective: In this research program, we aim to deepen our understanding of how therapeutic conversations support familiesand individuals experiencing burdening health and illness issues and how the FSCU laboratory setting supports the learning ofstudents, clinical trainees, and health care professionals.Methods: Here we apply a transformational action research design, including parallel and subsequent substudies, to advanceknowledge and practice in family systems care. Qualitative multiple-case study designs will be used to explore the benefits oftherapeutic conversations by analyzing recordings of the therapeutic conversations. The learning processes of students, trainees,and professionals will be investigated with descriptive qualitative study designs based on single and focus group interviews. Thedata will be analyzed with established coding methods.Results: Therapeutic conversations have been investigated in 3 single-case studies, each involving a sequence of 3 therapeuticconversation units. Data collection regarding the second research question is planned.Conclusions: Preliminary results confirm the therapeutic conversations to support families'coping. This renders the FSCU asetting for ethically sensitive research. This program will not only support the health and well-being of families, but also contributeto relieving the financial and workforce burdens in the health and social care system