Landscape of somatic mutations and clonal evolution in NUP98-rearranged adult acute myeloid leukaemia

被引：0
|
作者：
Frerich, Candace [1 ,2 ]
Li, Peng [3 ]
Raess, Philipp W. [1 ]
Dunlap, Jennifer [1 ]
Lachowiez, Curtis [4 ]
Solis-Ruiz, Jose [2 ]
Press, Richard [1 ,2 ]
Long, Nicola [2 ]
Swords, Ronan T. [4 ]
Wiszniewska, Joanna [1 ]
Fan, Guang [1 ]
Xie, Wei [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Pathol & Lab, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR USA
[3] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Dept Hematol & Med Oncol, Portland, OR USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年
关键词：
acute leukaemia; cytogenetics of leukaemia; molecular haematology; myeloid leukaemia; translocation; NUP98;
D O I：
10.1111/bjh.19962
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute myeloid leukaemia with NUP98 rearrangement (AML-NUP98) has been previously described in paediatric patients, and the clinical significance in adult AML patients remains largely unexplored. In this study, we identified specific partner fusion genes and examined somatic co-mutations and clonal evolution longitudinally in adult AML-NUP98 patients. Our comprehensive analysis provides an understanding of NUP98 rearrangement and co-mutations influencing clonal evolution and disease progression and offers valuable insights into potential therapeutic strategies. Further multiple centre studies are needed to investigate this entity in adult patients and improve treatment strategy.
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页数：6
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