Landscape of somatic mutations and clonal evolution in NUP98-rearranged adult acute myeloid leukaemia

被引：0
|
作者：
Frerich, Candace [1 ,2 ]
Li, Peng [3 ]
Raess, Philipp W. [1 ]
Dunlap, Jennifer [1 ]
Lachowiez, Curtis [4 ]
Solis-Ruiz, Jose [2 ]
Press, Richard [1 ,2 ]
Long, Nicola [2 ]
Swords, Ronan T. [4 ]
Wiszniewska, Joanna [1 ]
Fan, Guang [1 ]
Xie, Wei [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Pathol & Lab, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR USA
[3] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Dept Hematol & Med Oncol, Portland, OR USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年
关键词：
acute leukaemia; cytogenetics of leukaemia; molecular haematology; myeloid leukaemia; translocation; NUP98;
D O I：
10.1111/bjh.19962
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute myeloid leukaemia with NUP98 rearrangement (AML-NUP98) has been previously described in paediatric patients, and the clinical significance in adult AML patients remains largely unexplored. In this study, we identified specific partner fusion genes and examined somatic co-mutations and clonal evolution longitudinally in adult AML-NUP98 patients. Our comprehensive analysis provides an understanding of NUP98 rearrangement and co-mutations influencing clonal evolution and disease progression and offers valuable insights into potential therapeutic strategies. Further multiple centre studies are needed to investigate this entity in adult patients and improve treatment strategy.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations
    Lavallee, V-P
    Lemieux, S.
    Boucher, G.
    Gendron, P.
    Boivin, I.
    Girard, S.
    Hebert, J.
    Sauvageau, G.
    LEUKEMIA, 2016, 30 (07) : 1621 - 1624
  • [22] The landscape of somatic mutations in the core -binding factor acute myeloid leukemias
    Gedman, Amanda Larson
    Cheng, Jinjun
    Chen, Xiang
    Radtke, Ina
    Andersson, Anna
    Mulder, Heather
    Boggs, Kristy
    Vadodaria, Bhavin
    Yergeau, Donald
    Nakitandwe, Joy
    Bullinger, Lars
    Kuehn, Michael
    Doehner, Hartmut
    Doehner, Konstanze
    Shurtleff, Sheila
    Easton, John
    Wilson, Richard
    Zhang, Jinghui
    Downing, James R.
    CANCER RESEARCH, 2014, 74 (20)
  • [23] Landscape of somatic mutations in drug-resistant acute myeloid leukemia
    Eldfors, Samuli
    Kontro, Mika
    Akimov, Yevhen
    Kallioniemi, Olli
    Porkka, Kimmo
    Heckman, Caroline
    CANCER RESEARCH, 2017, 77
  • [24] CLONAL HETEROGENEITY IN PATIENT-DERIVED XENOGRAFT OF ADULT ACUTE MYELOID LEUKAEMIA
    Gonzales, F.
    Peyrouze, P.
    Boyer, T.
    Guihard, S.
    Helevaut, N.
    Preudhomme, J.
    Geffroy, S.
    Roumier, C.
    Quesnel, B.
    Preudhomme, C.
    Cheok, M.
    HAEMATOLOGICA, 2017, 102 : 360 - 361
  • [25] Clinical features of patients with acute myeloid leukaemia and the NUP98::NSD1 fusion gene
    Wu, An
    Liu, Yuntao
    Wei, Shuning
    Li, Yan
    Liu, Kaiqi
    Fang, Qiuyun
    Lin, Dong
    Gong, Benfa
    Zhang, Guangji
    Gong, Xiaoyuan
    Liu, Bingcheng
    Wang, Ying
    Mi, Yingchang
    Wei, Hui
    Wang, Jianxiang
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2023, 45 (04) : 589 - 591
  • [26] Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia
    Shiba, Norio
    Yoshida, Kenichi
    Shiraishi, Yuichi
    Okuno, Yusuke
    Yamato, Genki
    Hara, Yusuke
    Nagata, Yasunobu
    Chiba, Kenichi
    Tanaka, Hiroko
    Terui, Kiminori
    Kato, Motohiro
    Park, Myoung-ja
    Ohki, Kentaro
    Shimada, Akira
    Takita, Junko
    Tomizawa, Daisuke
    Kudo, Kazuko
    Arakawa, Hirokazu
    Adachi, Souichi
    Taga, Takashi
    Tawa, Akio
    Ito, Etsuro
    Horibe, Keizo
    Sanada, Masashi
    Miyano, Satoru
    Ogawa, Seishi
    Hayashi, Yasuhide
    BRITISH JOURNAL OF HAEMATOLOGY, 2016, 175 (03) : 476 - 489
  • [27] Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia
    Chen, Xiao
    Zhu, Han
    Qiao, Chun
    Zhao, Sishu
    Liu, Lu
    Wang, Yan
    Jin, Huimin
    Qian, Sixuan
    Wu, Yujie
    HEMATOLOGY, 2021, 26 (01) : 111 - 122
  • [28] Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A-Rearranged Acute Myeloid Leukemia
    Matsuo, Hidemasa
    Yoshida, Kenichi
    Nannya, Yasuhito
    Ito, Yuri
    Saito, Shoji
    Koga, Yuhki
    Moritake, Hiroshi
    Terui, Kiminori
    Kawaguchi, Koji
    Okamoto, Yasuhiro
    Nakayama, Hideki
    Miyako, Kanno
    Hino, Moeko
    Akane, Yusuke
    Inoue, Akiko
    Shimada, Akira
    Goto, Hiroaki
    Ueno, Hiroo
    Takita, Junko
    Yamato, Genki
    Shiba, Norio
    Hayashi, Yasuhide
    Shiraishi, Yuichi
    Miyano, Satoru
    Kiyokawa, Nobutaka
    Tomizawa, Daisuke
    Taga, Takashi
    Tawa, Akio
    Ogawa, Seishi
    Adachi, Souichi
    BLOOD, 2021, 138
  • [29] Identification of MYC mutations in acute myeloid leukemias with NUP98–NSD1 translocations
    V-P Lavallée
    S Lemieux
    G Boucher
    P Gendron
    I Boivin
    S Girard
    J Hébert
    G Sauvageau
    Leukemia, 2016, 30 : 1621 - 1624
  • [30] Evidence for allelic evolution of C/EBPalpha mutations in acute myeloid leukaemia
    Tiesmeier, J
    Czwalinna, A
    Müller-Tidow, C
    Krauter, J
    Serve, H
    Heil, G
    Ganser, A
    Verbeek, W
    BRITISH JOURNAL OF HAEMATOLOGY, 2003, 123 (03) : 413 - 419
12345