Landscape of somatic mutations and clonal evolution in NUP98-rearranged adult acute myeloid leukaemia

被引：0
|
作者：
Frerich, Candace [1 ,2 ]
Li, Peng [3 ]
Raess, Philipp W. [1 ]
Dunlap, Jennifer [1 ]
Lachowiez, Curtis [4 ]
Solis-Ruiz, Jose [2 ]
Press, Richard [1 ,2 ]
Long, Nicola [2 ]
Swords, Ronan T. [4 ]
Wiszniewska, Joanna [1 ]
Fan, Guang [1 ]
Xie, Wei [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Pathol & Lab, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR USA
[3] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Dept Hematol & Med Oncol, Portland, OR USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年
关键词：
acute leukaemia; cytogenetics of leukaemia; molecular haematology; myeloid leukaemia; translocation; NUP98;
D O I：
10.1111/bjh.19962
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute myeloid leukaemia with NUP98 rearrangement (AML-NUP98) has been previously described in paediatric patients, and the clinical significance in adult AML patients remains largely unexplored. In this study, we identified specific partner fusion genes and examined somatic co-mutations and clonal evolution longitudinally in adult AML-NUP98 patients. Our comprehensive analysis provides an understanding of NUP98 rearrangement and co-mutations influencing clonal evolution and disease progression and offers valuable insights into potential therapeutic strategies. Further multiple centre studies are needed to investigate this entity in adult patients and improve treatment strategy.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] The Transcriptomic Landscape of NUP98-Rearranged Pediatric Acute Myeloid Leukemia
    Smith, Jenny L.
    Bertrums, Eline J. M.
    Ries, Rhonda E.
    Ostronoff, Fabiana
    Leonti, Amanda R.
    Furlan, Scott N.
    Goemans, Bianca F.
    Meshinchi, Soheil
    BLOOD, 2020, 136
  • [2] Histone Acetyltransferases Are Critical Interacting Proteins in NUP98-Rearranged Acute Myeloid Leukemia
    Michmerhuizen, Nicole L.
    Umeda, Masayuki
    Iacobucci, Ilaria
    Arthur, Bright
    Di Giacomo, Danika
    Hiltenbrand, Ryan
    Portola, Pablo
    Abdelhamed, Sherif
    Huang, Hongling
    Zhou, Peipei
    Long, Lingyun
    Shi, Hao
    Sun, Yu
    Papachristou, Evangelia K.
    Chilamakuri, Chandra
    D'Santos, Clive S.
    Chi, Hongbo
    Klco, Jeffery M.
    Mullighan, Charles G.
    BLOOD, 2022, 140 : 2970 - 2971
  • [3] Clinicopathologic and Molecular Characterization of NUP98-Rearranged Acute Leukemias
    Sajjan, Sujata
    Oertling, Estelle E.
    Fuda, Franklin
    Gagan, Jeffrey
    Koduru, Prasad
    Garcia, Rolando
    Kwon, Adelaide
    Lin, Elisa
    Cantu, Miguel
    Wilson, Kathleen
    Weinberg, Olga K.
    Chen, Mingyi
    Jaso, Jesse Manuel
    Slone, Tamra L.
    Truscott, Jamie
    Thiebaud, Julio Alvarenga
    Chung, Stephen
    Madanat, Yazan F.
    Chen, Weina
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2025,
  • [4] Allogeneic stem cell transplantation can prolong the survival of patients with NUP98-rearranged acute myeloid leukemia
    Shen, Yuyan
    Zhang, Tingting
    Zhang, Lining
    Zhen, Sisi
    Chen, Zhangjie
    Zhang, Rongli
    Yang, Donglin
    Wei, Jialin
    He, Yi
    Jiang, Erlie
    Feng, Sizhou
    BONE MARROW TRANSPLANTATION, 2023, 58 (10) : 1149 - 1151
  • [5] Allogeneic stem cell transplantation can prolong the survival of patients with NUP98-rearranged acute myeloid leukemia
    Yuyan Shen
    Tingting Zhang
    Lining Zhang
    Sisi Zhen
    Zhangjie Chen
    Rongli Zhang
    Donglin Yang
    Jialin Wei
    Yi He
    Erlie Jiang
    Sizhou Feng
    Bone Marrow Transplantation, 2023, 58 : 1149 - 1151
  • [6] NUP98-rearranged acute myeloid leukemia expresses high levels of CDK6 and is hypersensitive to Palbociclib treatment
    Schmoellerl, J.
    Barbosa, I.
    Van der Veen, C.
    Eder, T.
    Schmidt, L.
    Brandstoetter, T.
    Maurer, B.
    Terlecki, S.
    Hoermann, G.
    Valent, P.
    Jude, J.
    Sexl, V.
    Zuber, J.
    Grebien, F.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 40 - 40
  • [7] The Histone Acetyltransferase MOZ (KAT6A) Is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia
    Michmerhuizen, Nicole L.
    Heikamp, Emily
    Umeda, Masayuki
    Iacobucci, Ilaria
    Arthur, Bright
    Di Giacomo, Danika
    Hiltenbrand, Ryan
    Radko-Juettner, Sandi
    Portola, Pablo
    Claquin, Aurelie
    Chandra, Bappaditya
    Baggett, David W.
    Huang, Hongling
    Zhou, Peipei
    Long, Lingyun
    Shi, Hao
    Sun, Yu
    Papachristou, Evangelia K.
    Chilamakuri, Chandra Sekhar Reddy
    Vitorino, Francisca N. de L.
    Gongora, Joanna M.
    D'Santos, Clive S.
    Garcia, Benjamin A.
    Kriwacki, Richard W.
    Chi, Hongbo
    Kentsis, Alex
    Armstrong, Scott A.
    Klco, Jeffery M.
    Mullighan, Charles G.
    BLOOD, 2024, 144 : 825 - 826
  • [8] NUP98-Rearranged Acute Myeloid Leukemia Stem Cells Superimpose Type I Interferon Signaling with Canonical Self-Renewal Programs
    Li, Yanan
    Yang, Wei
    Patel, Riddhi M.
    Casey, Emily B.
    Denby, Elisabeth
    Magee, Jeffrey
    BLOOD, 2023, 142
  • [9] Identification of a recurrent fusion NUP98-RARG in acute myeloid leukaemia resembling acute promyelocytic leukaemia
    Wang, Man
    Lin, Haiqing
    Chu, Xiaoxia
    Wang, Zheng
    Yang, Xiaofei
    Cen, Jiannong
    Shen, Hongjie
    Pan, Jinlan
    Wang, Yan
    Shen, Hongshi
    Chen, Suning
    Zhang, Xinyou
    Wen, Lijun
    Yao, Li
    BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 (06) : E73 - E78
  • [10] Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?
    Grove, Carolyn S.
    Vassiliou, George S.
    DISEASE MODELS & MECHANISMS, 2014, 7 (08) : 941 - 951
12345