Synthesis of 4-Cyclobutene-Isoquinolines From Aryl Imidates by Ru(II)-Catalyzed Domino C-H Activation/Cyclization

被引：0
|
作者：
Wang, Min [1 ,2 ]
Gao, Lei [2 ,3 ]
Miao, Maozhong [3 ]
Zong, Qianshou [2 ]
Ling, Fei [1 ]
Yao, Jinzhong [2 ]
Zhou, Hongwei [2 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharm, Hangzhou, Zhejiang, Peoples R China
[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing, Zhejiang, Peoples R China
[3] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Hangzhou, Zhejiang, Peoples R China
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2025年 / 39卷 / 03期
基金：
中国国家自然科学基金;
关键词：
aryl imidates; C-H activation; domino cyclization; isoquinolines; Ru-catalyzed; HETEROCYCLES; DISCOVERY;
D O I：
10.1002/aoc.7896
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A highly regioselective approach for constructing 4-cyclobutene-isoquinoline derivatives through ruthenium-catalyzed domino C-H activation/cyclization of aryl imidates has been demonstrated. This new transformation tolerates various substituted functional groups on imidates and propargylic monofluoroalkynes, resulting in the corresponding products being delivered in moderate yields.
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页数：6
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