Synthesis of 4-Cyclobutene-Isoquinolines From Aryl Imidates by Ru(II)-Catalyzed Domino C-H Activation/Cyclization

被引：0

作者：

Wang, Min ^{[1
,2
]}

Gao, Lei ^{[2
,3
]}

Miao, Maozhong ^{[3
]}

Zong, Qianshou ^{[2
]}

Ling, Fei ^{[1
]}

Yao, Jinzhong ^{[2
]}

Zhou, Hongwei ^{[2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharm, Hangzhou, Zhejiang, Peoples R China

[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing, Zhejiang, Peoples R China

[3] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Hangzhou, Zhejiang, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2025年 / 39卷 / 03期

基金：

中国国家自然科学基金;

关键词：

aryl imidates; C-H activation; domino cyclization; isoquinolines; Ru-catalyzed; HETEROCYCLES; DISCOVERY;

D O I：

10.1002/aoc.7896

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly regioselective approach for constructing 4-cyclobutene-isoquinoline derivatives through ruthenium-catalyzed domino C-H activation/cyclization of aryl imidates has been demonstrated. This new transformation tolerates various substituted functional groups on imidates and propargylic monofluoroalkynes, resulting in the corresponding products being delivered in moderate yields.

引用

页数：6

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