The relationship between anxiety and levels of Alzheimer's disease plasma biomarkers

被引：0
|
作者：
Bernard, Mark A. [1 ,2 ]
Boutajangout, Allal [1 ,2 ]
Debure, Ludovic [1 ,2 ]
Ahmed, Wajiha [1 ,2 ]
Briggs, Anthony Q. [1 ,2 ]
Boza-Calvo, Carolina [2 ,3 ,4 ]
Vedvyas, Alok [1 ,2 ]
Marsh, Karyn [1 ,2 ]
Bubu, Omonigho M. [1 ,2 ,5 ]
Osorio, Ricardo S. [2 ,5 ]
Wisniewski, Thomas [1 ,2 ,6 ]
Masurkar, Arjun, V [1 ,2 ,6 ]
机构：
[1] NYU, Ctr Cognit Neurol, Dept Neurol, Grossman Sch Med, New York, NY 10016 USA
[2] NYU, Alzheimers Dis Res Ctr, Grossman Sch Med, New York, NY 10012 USA
[3] Univ Costa Rica, Ctr Invest Hematol & Trastornos Afines CIHATA, San Jose, Costa Rica
[4] Univ Costa Rica, Escuela Med, San Jose, Costa Rica
[5] NYU, Grossman Sch Med, Dept Psychiat, New York, NY USA
[6] NYU, Neurosci Inst, Grossman Sch Med, New York, NY USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2024年 / 102卷 / 04期
关键词：
Alzheimer's disease; anxiety; biomarkers; dementia; plasma; MILD BEHAVIORAL IMPAIRMENT; NEUROPSYCHIATRIC SYMPTOMS; COGNITIVE IMPAIRMENT; DEMENTIA; RISK; ASSOCIATION; COHORT;
D O I：
10.1177/13872877241295324
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with cerebrospinal fluid/positron emission tomography biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/amyloid-beta(42) ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
引用
收藏
页码：987 / 993
页数：7
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