The relationship between anxiety and levels of Alzheimer's disease plasma biomarkers

被引：0
|
作者：
Bernard, Mark A. [1 ,2 ]
Boutajangout, Allal [1 ,2 ]
Debure, Ludovic [1 ,2 ]
Ahmed, Wajiha [1 ,2 ]
Briggs, Anthony Q. [1 ,2 ]
Boza-Calvo, Carolina [2 ,3 ,4 ]
Vedvyas, Alok [1 ,2 ]
Marsh, Karyn [1 ,2 ]
Bubu, Omonigho M. [1 ,2 ,5 ]
Osorio, Ricardo S. [2 ,5 ]
Wisniewski, Thomas [1 ,2 ,6 ]
Masurkar, Arjun, V [1 ,2 ,6 ]
机构：
[1] NYU, Ctr Cognit Neurol, Dept Neurol, Grossman Sch Med, New York, NY 10016 USA
[2] NYU, Alzheimers Dis Res Ctr, Grossman Sch Med, New York, NY 10012 USA
[3] Univ Costa Rica, Ctr Invest Hematol & Trastornos Afines CIHATA, San Jose, Costa Rica
[4] Univ Costa Rica, Escuela Med, San Jose, Costa Rica
[5] NYU, Grossman Sch Med, Dept Psychiat, New York, NY USA
[6] NYU, Neurosci Inst, Grossman Sch Med, New York, NY USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2024年 / 102卷 / 04期
关键词：
Alzheimer's disease; anxiety; biomarkers; dementia; plasma; MILD BEHAVIORAL IMPAIRMENT; NEUROPSYCHIATRIC SYMPTOMS; COGNITIVE IMPAIRMENT; DEMENTIA; RISK; ASSOCIATION; COHORT;
D O I：
10.1177/13872877241295324
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with cerebrospinal fluid/positron emission tomography biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/amyloid-beta(42) ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
引用
收藏
页码：987 / 993
页数：7
相关论文
共 50 条
  • [21] Plasma tau levels in Alzheimer's disease
    Henrik Zetterberg
    David Wilson
    Ulf Andreasson
    Lennart Minthon
    Kaj Blennow
    Jeffrey Randall
    Oskar Hansson
    Alzheimer's Research & Therapy, 5
  • [22] Plasma levels of neuropeptides in Alzheimer's disease
    Proto, Caterina
    Romualdi, Daniela
    Cento, Rosa Maria
    Spada, Rosario S.
    Di Mento, Giuseppina
    Ferri, Raffaele
    Lanzone, Antonio
    GYNECOLOGICAL ENDOCRINOLOGY, 2006, 22 (04) : 213 - 218
  • [23] THE RELATIONSHIP BETWEEN NEUROPSYCHIATRIC SYMPTOMS, NIGHTTIME BEHAVIORS, AND ALZHEIMER'S DISEASE CSF BIOMARKERS
    Zhang, Meina
    Cho, Young-Eun
    Moon, Chooza
    INNOVATION IN AGING, 2021, 5 : 652 - 652
  • [24] Relationship Between β-Secretase, Inflammation and Core Cerebrospinal Fluid Biomarkers for Alzheimer's Disease
    Alcolea, Daniel
    Carmona-Iragui, Maria
    Suarez-Calvet, Marc
    Belen Sanchez-Saudinos, M.
    Sala, Isabel
    Anton-Aguirre, Sofia
    Blesa, Rafael
    Clarimon, Jordi
    Fortea, Juan
    Lleo, Alberto
    JOURNAL OF ALZHEIMERS DISEASE, 2014, 42 (01) : 157 - 167
  • [25] Race modifies the relationship between cognition and Alzheimer’s disease cerebrospinal fluid biomarkers
    Jennifer C. Howell
    Kelly D. Watts
    Monica W. Parker
    Junjie Wu
    Alexander Kollhoff
    Thomas S. Wingo
    Cornelya D. Dorbin
    Deqiang Qiu
    William T. Hu
    Alzheimer's Research & Therapy, 9
  • [26] Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers
    Howell, Jennifer C.
    Watts, Kelly D.
    Parker, Monica W.
    Wu, Junjie
    Kollhoff, Alexander
    Wingo, Thomas S.
    Dorbin, Cornelya D.
    Qiu, Deqiang
    Hu, William T.
    ALZHEIMERS RESEARCH & THERAPY, 2017, 9
  • [27] Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease
    Dukart, Juergen
    Mueller, Karsten
    Villringer, Arno
    Kherif, Ferath
    Draganski, Bogdan
    Frackowiak, Richard
    Schroeter, Matthias L.
    NEUROIMAGE-CLINICAL, 2013, 3 : 84 - 94
  • [28] A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer's Disease
    Chen, Tianle
    Hutchison, R. M.
    Rubel, C.
    Murphy, J.
    Xie, J.
    Montenigro, P.
    Cheng, W.
    Fraser, K.
    Dent, G.
    Hendrix, S.
    Hansson, O.
    Aisen, P.
    Tian, Y.
    O'Gorman, J.
    JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2024, 11 (05): : 1228 - 1240
  • [29] The Relationship Between Anxiety and Alzheimer's Disease (vol 5, pg 171, 2021)
    Mendez, Mario F.
    JOURNAL OF ALZHEIMERS DISEASE REPORTS, 2021, 5 (01) : 563 - 563
  • [30] Biomarkers of Alzheimer Disease in Plasma
    Irizarry M.C.
    NeuroRX, 2004, 1 (2): : 226 - 234
12345