Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression

被引：0

作者：

Corvo, Cassandre ^{[1
]}

Mendez-David, Indira ^{[2
]}

Goutal, Sebastien ^{[1
]}

Saba, Wadad ^{[1
]}

Bottlaender, Michel ^{[1
]}

Caille, Fabien ^{[1
]}

Hen, Rene ^{[3
,4
]}

Colle, Romain ^{[2
]}

Corruble, Emmanuelle ^{[2
]}

Tournier, Nicolas ^{[1
]}

Leroy, Claire ^{[1
]}

David, Denis J. ^{[2
]}

机构：

[1] Univ Paris Saclay, Serv Hosp Frederic Joliot, INSERM, CNRS,CEA,Lab Imagerie Biomed Multimodale BioMaps, F-91401 Orsay, France

[2] Univ Paris Saclay, Ctr Rech Epidemiol & Sante Populat CESP, Inserm, UMR 1018,Team Moods, F-91400 Orsay, France

[3] Columbia Univ, Dept Psychiat, New York, NY 10027 USA

[4] New York State Psychiat Inst & Hosp, Div Integrat Neurosci, New York, NY 10019 USA

来源：

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2025年 / 8卷 / 02期

关键词：

Major depressive disorder; CORT model; Synapticdensity; Antidepressant; Positron emission tomography; NEUROGENESIS; FLUOXETINE; ANXIETY;

D O I：

10.1021/acsptsci.4c00621

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this preclinical pilot study, we used [11C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. PET imaging was performed in a validated mouse model of depression/anxiety (CORT model), and the effect of 5-week treatment with fluoxetine was tested. Depression/anxiety phenotype and antidepressant action of fluoxetine were confirmed using the novelty-suppressed feeding test, previously validated in the CORT model. PET data showed significant decreases of volume of distribution (V T) of [11C]UCB-J in most brain regions of CORT mice compared with controls after 5 weeks of fluoxetine, and a trend toward restoration of V T values to control levels was observed, although it reached significance only in the olfactory bulb. These preliminary data support the use of [11C]UCB-J PET imaging and the CORT model to study the synaptic modulation of antidepressants. It provides excellent translational opportunities to study the relationship between synaptic plasticity and the clinical efficacy of antidepressants.

引用

页码：339 / 345

页数：7

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