Electro-Oxidative Three-Component Synthesis of 3,5-Disubstituted-1,2,4-Thiadiazoles from Amines, Amidines, and CS2

被引：0

作者：

Huang, Peng-Fei ^{[1
]}

Peng, Ying ^{[1
]}

Fu, Jia-Le ^{[1
]}

Li, Bo ^{[1
]}

Zhou, Quan ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年

基金：

中国国家自然科学基金;

关键词：

S BOND FORMATION; ONE-POT SYNTHESIS; INHIBITORS; 1,2,4-THIADIAZOLES; WATER;

D O I：

10.1021/acs.joc.4c02569

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,4-Thiadiazoles, a significant class of heterocyclic compounds, are widely found in biologically active molecules. Herein, we report a green electrochemical three-component reaction of amines, amidines, and CS2 for the effective synthesis of 3,5-disubstituted-1,2,4-thiadiazoles under metal- and oxidant-free conditions. Both aliphatic and aryl amines are well-tolerated at room temperature in a simple undivided cell. A series of 1,2,4-thiadiazoles are prepared with excellent functional groups.

引用

页数：10

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