High yielding protocol for oxidative dimerization of primary thioamides: a strategy toward 3,5-disubstituted 1,2,4-thiadiazoles

被引：26
|
作者：
Vanajatha, G. [1 ]
Reddy, V. Prabhakar [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, TS, India
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 22期
关键词：
Primary thioamides; Ceric ammonium nitrate; Oxidative dimerization; Symmetrically; Thiadiazoles; CERIUM(IV) AMMONIUM-NITRATE; MEDICINAL CHEMISTRY; DIARYL SELENOXIDE; ORGANIC-SYNTHESIS; MILD-STEEL; INHIBITORS; TRIBROMIDE; CONVERSION; MEDIA;
D O I：
10.1016/j.tetlet.2016.04.029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ceric ammonium nitrate (CAN), a highly versatile reagent, was found to efficiently mediate the oxidative dimerization of primary thioamides in acetonitrile at room temperature leading to the rapid and expeditious synthesis of symmetrically 3,5-disubstituted 1,2,4-thiadiazoles in high yields. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2356 / 2359
页数：4
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