PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis

被引：2
|
作者：
Chu, Fengyun [1 ]
Hou, Peili [1 ,2 ]
Zhu, Hongchao [1 ]
Gao, Yan [1 ]
Wang, Xiaomeng [1 ]
He, Wenqi [3 ]
Ren, Juan [1 ]
Li, Min [1 ]
Liu, Yu [1 ]
He, Daniel Chang [4 ]
Wang, Hongmei [1 ]
Gao, Yuwei [1 ,5 ]
He, Hongbin [1 ,2 ]
机构：
[1] Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Key Lab Anim Resistant Biol Shandong, Jinan 250358, Peoples R China
[2] Shandong Agr Univ, Coll Vet Med, Dept Prevent Vet Med, Tai An 271018, Peoples R China
[3] Jilin Univ, Coll Vet Med, State Key Lab Zoonosis Res, Minist Educ, Changchun 130062, Peoples R China
[4] Univ North Carolina Chapel Hill, Coll Arts & Sci, Chapel Hill, NC 27599 USA
[5] Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2024年 / 121卷 / 49期
关键词：
PBLD; MAVS; USP4; RNA viruses; Type; IFN; NF-KAPPA-B; RIG-I; TUMOR-SUPPRESSOR; VIRUS-INFECTION; CELL-DEATH; P53; PROTEIN; MAVS; DEUBIQUITINATION; PHOSPHORYLATION;
D O I：
10.1073/pnas.2401174121
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Phenazine biosynthesis- like domain- containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections. We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin- specific protease transcription of USP4 via the upregulation of p53. USP4, which is a MAVS- interacting antiviral innate immunity through the p53-USP4-MAVS signaling, providing a preliminary basis for research on PBLD as a target molecule for treating RNA virus infection.
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页数：12
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