Impact of the N-Heterocyclic Carbene (NHC) Ligand on the trans-[Pd(NHC)(NH2 n Bu)Cl2] Precatalyst Architecture in C-N Bond-Forming Reactions

被引：0

作者：

Pozsoni, Nestor Bracho ^{[1
,2
]}

Nahra, Fady ^{[1
,2
,3
]}

van Hecke, Kristof ^{[1
,2
]}

Cazin, Catherine S. J. ^{[1
,2
]}

Nolan, Steven P. ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Chem, B-9000 Ghent, Belgium

[2] Univ Ghent, Ctr Sustainable Chem, B-9000 Ghent, Belgium

[3] VITO Flemish Inst Technol Res, Mat & Chem MATCH Unit, B-2400 Mol, Belgium

来源：

ORGANOMETALLICS | 2024年 / 43卷 / 22期

关键词：

CROSS-COUPLING REACTIONS; PALLADIUM CATALYSTS; CONVERSION;

D O I：

10.1021/acs.organomet.4c00419

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two straightforward synthetic procedures leading to air- and moisture-stable trans-[Pd(NHC)(NH2 n Bu)Cl2] precatalysts are presented. These complexes, obtained by adding n-butylamine to [Pd(NHC)(mu-Cl)Cl]2 or trans-[Pd(NHC)(DMS)Cl2] precursors (DMS, dimethyl sulfide), demonstrate superior catalytic activity compared to their DMS counterparts in Buchwald-Hartwig amination reactions. Utilizing a more sustainable solvent (2-MeTHF), the catalyst loading was halved to 0.1 mol %, establishing this new system as a highly efficient and environmentally more friendly alternative to previous systems.

引用

页码：2963 / 2971

页数：9

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