Impact of the N-Heterocyclic Carbene (NHC) Ligand on the trans-[Pd(NHC)(NH2 n Bu)Cl2] Precatalyst Architecture in C-N Bond-Forming Reactions

被引：0
|
作者：
Pozsoni, Nestor Bracho [1 ,2 ]
Nahra, Fady [1 ,2 ,3 ]
van Hecke, Kristof [1 ,2 ]
Cazin, Catherine S. J. [1 ,2 ]
Nolan, Steven P. [1 ,2 ]
机构：
[1] Univ Ghent, Dept Chem, B-9000 Ghent, Belgium
[2] Univ Ghent, Ctr Sustainable Chem, B-9000 Ghent, Belgium
[3] VITO Flemish Inst Technol Res, Mat & Chem MATCH Unit, B-2400 Mol, Belgium
来源：
ORGANOMETALLICS | 2024年 / 43卷 / 22期
关键词：
CROSS-COUPLING REACTIONS; PALLADIUM CATALYSTS; CONVERSION;
D O I：
10.1021/acs.organomet.4c00419
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two straightforward synthetic procedures leading to air- and moisture-stable trans-[Pd(NHC)(NH2 n Bu)Cl2] precatalysts are presented. These complexes, obtained by adding n-butylamine to [Pd(NHC)(mu-Cl)Cl]2 or trans-[Pd(NHC)(DMS)Cl2] precursors (DMS, dimethyl sulfide), demonstrate superior catalytic activity compared to their DMS counterparts in Buchwald-Hartwig amination reactions. Utilizing a more sustainable solvent (2-MeTHF), the catalyst loading was halved to 0.1 mol %, establishing this new system as a highly efficient and environmentally more friendly alternative to previous systems.
引用
收藏
页码：2963 / 2971
页数：9
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