Peptide Multifunctionalization via Modular Construction of Trans-AB2C Porphyrin on Resin

被引:0
|
作者
Wu, Yue [1 ]
Wong, Yuen-Ting [1 ]
Yeung, Yik-Hoi [1 ]
Lam, Pak-Lun [1 ]
Chau, Ho-Fai [1 ]
Tam, Wing-Sze [2 ]
Zhang, Qian [1 ]
Tai, William C. S. [1 ]
Wong, Ka-Leung [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, 11 Yuk Choi Rd, Hong Kong, Peoples R China
[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, 224 Waterloo Rd, Hong Kong, Peoples R China
关键词
multifunctional peptide; peptide ligation; porphyrin; porphyrin-peptide conjugates; solid-phase peptide synthesis; NANOPARTICLES; PET; DESIGN; PHOTOSENSITIZER; THERAPY; PROBES;
D O I
10.1002/advs.202409771
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Peptide multifunctionalization is a crucial technique to develop peptide-based agents for various purposes. Porphyrin-peptide conjugates are a class of popular multifunctional peptides renowned for their multifunctional and multimodal properties. However, the tedious synthetic works for porphyrin building blocks are involved in most previous studies. In this work, a modular solid-phase synthetic approach is reported to construct trans-AB2C porphyrin on peptide chains without presynthesized porphyrin building blocks. The products from this approach, which inherit both functionalities from the porphyrins and the modules employed for constructing porphyrins, show potential in biomedical and biomaterial applications. Furthermore, by extending this synthetic approach, the first example of "resin-to-resin" reaction is reported to link two peptides together along the construction of porphyrin motifs to give porphyrin-peptide conjugates with two different peptide chains.
引用
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页数:9
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