Neutrophil extracellular traps in wound healing

被引：1
|
作者：
Zhu, Zhanyong [1 ]
Zhou, Shengzhi [1 ]
Li, Sicheng [1 ]
Gong, Song [2 ]
Zhang, Qi [3 ,4 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Plast Surg, Wuhan 430060, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Jiefang Rd 1095, Wuhan 430030, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast & Cosmet Surg, Wuhan 430030, Peoples R China
[4] Hubei Univ Sci & Technol, Xianning Med Coll, Xianning 437000, Hubei, Peoples R China
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2024年 / 45卷 / 11期
关键词：
MECHANISMS; STRATEGY; NETOSIS;
D O I：
10.1016/j.tips.2024.09.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Wound healing is a complex and orchestrated process that involves hemostasis, inflammation, proliferation, and tissue remodeling. Neutrophil extracellular traps (NETs) are intricate web-like structures released by neutrophils, comprising decondensed chromatin, myeloperoxidase (MPO), and neutrophil elastase (NE), which play vital roles in regulating neutrophil-mediated immune regulation. While NETs contribute to wound healing, excessive activation induced by dysregulated inflammation can hinder the healing process. Understanding the pivotal role of NETs in wound healing and tissue remodeling, as well as their intricate interactions within the wound microenvironment, presents opportunities for innovative wound healing strategies. In this review we discuss the process of NET formation, explore the interactions between NETs and skin cells, and examine therapeutic strategies targeting NETs and drug delivery platforms to accelerate wound healing. Additionally, we discuss current clinical investigations and research challenges towards advancing wound care practices.
引用
收藏
页码：1033 / 1045
页数：13
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