Transition-Metal-Catalyzed Asymmetric Reduction of 2-Pyridine Ketones

被引：0
|
作者：
Vasudevan, Vidhul [1 ]
Harishankar, M. S. [1 ]
Ollevier, Thierry [1 ]
机构：
[1] Univ Laval, Dept Chim, 1045 Ave Medecine, Quebec City, PQ G1V 0A6, Canada
来源：
SYNOPEN | 2024年 / 08卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
asymmetric reduction; ketones; transfer hydrogenation; hydrogenation; hydrosilylation; iron catalysis; ENANTIOSELECTIVE TRANSFER HYDROGENATION; HETEROARYL KETONES; PINCER RUTHENIUM; RHODIUM COMPLEX; HYDROSILYLATION; LIGANDS; ARYL; ALCOHOLS; CONSTRUCTION; DERIVATIVES;
D O I：
10.1055/a-2501-4247
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This graphical review provides a concise overview of transition-metal-catalyzed asymmetric reduction of 2-pyridine ketones to produce enantiopure chiral 2-pyridine aryl/alkyl alcohols, which are present in many chiral ligands and pharmaceuticals. Key methods include metal-catalyzed hydrogenation, transfer hydrogenation, and hydrosilylation, with a focus on sustainable catalysts like iron and manganese. This review serves as a foundation for future advancements in sustainable and enantioselective keto group reductions.
引用
收藏
页码：387 / 400
页数：14
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