Transition-Metal-Catalyzed Asymmetric Reduction of 2-Pyridine Ketones

被引：0

作者：

Vasudevan, Vidhul ^{[1
]}

Harishankar, M. S. ^{[1
]}

Ollevier, Thierry ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, 1045 Ave Medecine, Quebec City, PQ G1V 0A6, Canada

来源：

SYNOPEN | 2024年 / 08卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

asymmetric reduction; ketones; transfer hydrogenation; hydrogenation; hydrosilylation; iron catalysis; ENANTIOSELECTIVE TRANSFER HYDROGENATION; HETEROARYL KETONES; PINCER RUTHENIUM; RHODIUM COMPLEX; HYDROSILYLATION; LIGANDS; ARYL; ALCOHOLS; CONSTRUCTION; DERIVATIVES;

D O I：

10.1055/a-2501-4247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This graphical review provides a concise overview of transition-metal-catalyzed asymmetric reduction of 2-pyridine ketones to produce enantiopure chiral 2-pyridine aryl/alkyl alcohols, which are present in many chiral ligands and pharmaceuticals. Key methods include metal-catalyzed hydrogenation, transfer hydrogenation, and hydrosilylation, with a focus on sustainable catalysts like iron and manganese. This review serves as a foundation for future advancements in sustainable and enantioselective keto group reductions.

引用

页码：387 / 400

页数：14

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