Co-occurrence of Neuromyelitis Optica Spectrum Disorder and Idiopathic Multicentric Castleman Disease Successfully Treated with Tocilizumab: A Case Report

被引：0

作者：

Wada, Takuma Tsuzuki ^{[1
]}

Yokota, Kazuhiro ^{[1
]}

Okada, Mariko ^{[2
]}

Ichimura, Takaya ^{[3
]}

Ueno, Takehito ^{[1
]}

Okumura, Nobuhito ^{[1
]}

Osawa, Iichiro ^{[4
]}

Inoue, Kaiji ^{[4
]}

Akiyama, Yuji ^{[1
]}

Nakazato, Yoshihiko ^{[2
]}

Sasaki, Atsushi

Yamamoto, Toshimasa ^{[2
]}

Mimura, Toshihide ^{[1
]}

机构：

[1] Saitama Med Univ, Fac Med, Dept Rheumatol & Appl Immunol, Irama, Japan

[2] Saitama Med Univ, Fac Med, Dept Neurol, Saitama, Japan

[3] Saitama Med Univ, Fac Med, Dept Pathol, Saitama, Japan

[4] Saitama Med Univ Hosp, Dept Radiol, Saitama, Japan

来源：

INTERNAL MEDICINE | 2024年

关键词：

neuromyelitis optica spectrum disorder; Castleman disease; interleukin-6; tocilizumab; ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY; DIAGNOSTIC-CRITERIA; EFFICACY; PLASMABLASTS; SATRALIZUMAB; AQUAPORIN-4; SAFETY;

D O I：

10.2169/internalmedicine.4503-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a 52-year-old woman with anti-aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) and idiopathic multicentric Castleman disease (iMCD) who was successfully treated with tocilizumab, a humanized anti-human interleukin (IL)-6 receptor monoclonal antibody. This is the first report of a case of coexisting NMOSD and iMCD. IL-6 is involved in the pathogenesis of both NMOSD and iMCD, and tocilizumab is effective against both diseases. By treating the patient with tocilizumab, the lung lesions due to iMCD improved, and the neurological symptoms of NMOSD did not recur.

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页数：7

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