Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent

被引：0

作者：

Zhumakova, Symbat ^{[1
,2
]}

Tokusheva, Aliya ^{[3
]}

Zharkynbek, Tolganay ^{[1
]}

Balabekova, Marina ^{[3
]}

Koks, Sulev ^{[4
]}

Seilkhanov, Tulegen ^{[5
]}

Dembitsky, Valery ^{[6
]}

Zazybin, Alexey ^{[2
]}

Aydemir, Murat ^{[7
]}

Kemelbekov, Ulan ^{[1
,8
]}

Kairanbayeva, Gulgul ^{[3
]}

Yu, Valentina ^{[1
]}

机构：

[1] AB Bekturov Inst Chem Sci, Lab Chem Synthet & Nat Med Cpds Chem, 106 Sh Ualikhanov St, Alma Ata 050010, Kazakhstan

[2] Kazakh British Tech Univ, Sch Chem Engn, 59 Tole Bi St, Alma Ata 050000, Kazakhstan

[3] Asfendiyarov Kazakh Natl Med Univ, Dept Pathol Physiol, 94 Tole Bi St, Alma Ata 050000, Kazakhstan

[4] Murdoch Univ, Hlth Futures Inst, 90 South St, Perth, WA 6150, Australia

[5] Sh Ualikhanov Kokshetau State Univ, Lab Engn Profile NMR Spect, 76 Abai St, Kokshetau 020000, Kazakhstan

[6] Lethbridge Coll, Ctr Appl Res Innovat & Entrepreneurship, 3000 Coll Dr South, Lethbridge, AB T1K 1L6, Canada

[7] Dicle Univ, Fac Sci, Dept Chem, TR-21280 Diyarbakir, Turkiye

[8] South Kazakhstan Med Acad, 1 Al Farabi Sq, Shymkent 160019, Kazakhstan

来源：

MOLECULES | 2024年 / 29卷 / 21期

关键词：

1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (<bold>EPPP</bold>); complex <bold>EPPP</bold> with beta-cyclodextrin (<bold>EPPP beta CD</bold>); supracomplex; aseptic inflammation; heavy metal technology-related exposure; ammonium vanadate (NH4VO3); potassium bichromate (K2Cr2O7); T-CELLS; CANCER;

D O I：

10.3390/molecules29215135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with beta-cyclodextrin (EPPP beta CD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPP beta CD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPP beta CD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPP beta CD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.

引用

页数：12

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