Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes

被引：0
|
作者：
Meyer-Luehmann, Melanie [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Neurol & Clin Neurosci, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
TRENDS IN NEUROSCIENCES | 2025年 / 48卷 / 03期
关键词：
D O I：
10.1016/j.tins.2025.01.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia are known to be involved in the modulation of amyloid-beta (A beta) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger A beta aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal A beta , amongst other processes, in the growth and spread of fibrillary A beta .
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收藏
页码：174 / 175
页数：2
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