Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes

被引：0
|
作者：
Meyer-Luehmann, Melanie [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Neurol & Clin Neurosci, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
TRENDS IN NEUROSCIENCES | 2025年 / 48卷 / 03期
关键词：
D O I：
10.1016/j.tins.2025.01.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia are known to be involved in the modulation of amyloid-beta (A beta) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger A beta aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal A beta , amongst other processes, in the growth and spread of fibrillary A beta .
引用
收藏
页码：174 / 175
页数：2
相关论文
共 50 条
  • [11] TGF-β1 and microglial clearance of amyloid-β
    不详
    NEUROSCIENTIST, 2001, 7 (04): : 276 - 277
  • [12] Microglia degrade Alzheimer's amyloid-beta deposits extracellularly via digestive exophagy
    Jacquet, Rudy G.
    Ibanez, Fernando Gonzalez
    Picard, Katherine
    Funes, Lucy
    Khakpour, Mohammadparsa
    Gouras, Gunnar K.
    Tremblay, Marie-Eve
    Maxfield, Frederick R.
    Sole-Domenech, Santiago
    CELL REPORTS, 2024, 43 (12):
  • [13] Identification of genes associated with amyloid-β-induced microglial activation
    Sebastiani, G
    Lagacé, C
    McLaughlin, RW
    Gervais, F
    Tremblay, P
    Dudal, S
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S228 - S228
  • [14] The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
    Weiguo Dong
    Christine M. Embury
    Yaman Lu
    Sarah M. Whitmire
    Bhagyalaxmi Dyavarshetty
    Harris A. Gelbard
    Howard E. Gendelman
    Tomomi Kiyota
    Journal of Neuroinflammation, 13
  • [15] The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
    Dong, Weiguo
    Embury, Christine M.
    Lu, Yaman
    Whitmire, Sarah M.
    Dyavarshetty, Bhagyalaxmi
    Gelbard, Harris A.
    Gendelman, Howard E.
    Kiyota, Tomomi
    JOURNAL OF NEUROINFLAMMATION, 2016, 13
  • [16] Mechanism of Amyloid-β Fibril Elongation
    Gurry, Thomas
    Stultz, Collin M.
    BIOCHEMISTRY, 2014, 53 (44) : 6981 - 6991
  • [17] Mitochondrial import and degradation of amyloid-β peptide
    Pinho, Catarina Moreira
    Teixeira, Pedro Filipe
    Glaser, Elzbieta
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2014, 1837 (07): : 1069 - 1074
  • [18] Microglial transplantation increases amyloid-β clearance in Alzheimer model rats
    Takata, Kazuyuki
    Kitamura, Yoshihisa
    Yanagisawa, Daijiro
    Morikawa, Shigehiro
    Morita, Masahito
    Inubushi, Toshiro
    Tsuchiya, Daiju
    Chishiro, Saori
    Saeki, Mana
    Taniguchi, Takashi
    Shimohama, Shun
    Tooyama, Ikuo
    FEBS LETTERS, 2007, 581 (03) : 475 - 478
  • [19] Microglial activation around amyloid-β deposits in mouse and rat models
    Takata, K
    Kitamura, Y
    Tsuchiya, D
    Taniguchi, T
    Shimohama, S
    SENESCENCE-ACCELERATED MOUSE (SAM): AN ANIMAL MODEL OF SENESCENCE, 2004, 1260 : 265 - 269
  • [20] Transplantation of microglial increases amyloid-β clearance in Alzheimer model rats
    Takata, Kazuyuki
    Kitamura, Yoshihisa
    Shimohama, Shun
    Tooyama, Ikuo
    Taniguchi, Takashi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 114P - 114P
12345