Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes

被引：0
|
作者：
Meyer-Luehmann, Melanie [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Neurol & Clin Neurosci, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
TRENDS IN NEUROSCIENCES | 2025年 / 48卷 / 03期
关键词：
D O I：
10.1016/j.tins.2025.01.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia are known to be involved in the modulation of amyloid-beta (A beta) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger A beta aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal A beta , amongst other processes, in the growth and spread of fibrillary A beta .
引用
收藏
页码：174 / 175
页数：2
相关论文
共 50 条
  • [1] Process and mechanism of microglial phagocytosis of amyloid-β peptide
    Tsuchiya, Daju
    Kitamura, Yoshihisa
    Shimohama, Shun
    Taniguchi, Takashi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, 125 : 108 - 110
  • [2] Orexin Impairs the Phagocytosis and Degradation of Amyloid-β Fibrils by Microglial Cells
    An, Hoyoung
    Cho, Mi-Hyang
    Kim, Dong-Hou
    Chung, Seockhoon
    Yoon, Seung-Yong
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 58 (01) : 253 - 261
  • [3] Microglial responses to amyloid-β species
    Cishiro, Saori
    Kitamura, Yoshihisa
    Takata, Kazuyuki
    Shimohama, Shun
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, 125 : 111 - 113
  • [4] Galantamine increases microglial phagocytosis of amyloid-β
    Terada, Maki
    Takata, Kazuyuki
    Kitamura, Yoshihisa
    Taniguchi, Takashi
    Shimohama, Shun
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 183P - 183P
  • [5] Clearance of amyloid-β in microglial culture model
    Tsuchiya, D
    Kitamura, Y
    Takata, K
    Taniguchi, T
    Shimohama, S
    SENESCENCE-ACCELERATED MOUSE (SAM): AN ANIMAL MODEL OF SENESCENCE, 2004, 1260 : 271 - 274
  • [6] Microglial amyloid-β clearance and regulatory factors
    Takata, K
    Kitamura, Y
    Tsuchiya, D
    Taniguchi, T
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 79P - 79P
  • [7] Importance of amyloid-β conformation in microglial interactions
    Nichols, M.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 42 - 42
  • [8] Regulation of microglial amyloid-β phagocytosis by anti-amyloid-β antibody
    Takata, Kazuyuki
    Kitamura, Yoshihisa
    Taniguchi, Takashi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 128P - 128P
  • [9] VEGF controls microglial phagocytic response to amyloid-β
    de Gea, Priscille
    Benkeder, Sarah
    Bouvet, Pauline
    Aimard, Melanie
    Chounlamountri, Naura
    Honnorat, Jerome
    Do, Le Duy
    Meissirel, Claire
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2023, 17
  • [10] Stress proteins and regulation of microglial amyloid-β phagocytosis
    Kitamura, Y
    Takata, K
    Taniguchi, T
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 31P - 31P
12345