A Cascade Synthesis of Furo-Pyrrolo-Pyridines via Pd(II)-Catalyzed Dual N-H/C Annulative-Cyclization

被引：2
|
作者：
Nath Dhara, Hirendra [1 ]
Manna, Supriya [1 ]
Patel, Bhisma K. [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2025年 / 31卷 / 04期
关键词：
Annulations; Fused heterocycles; Furo-pyrrolo-pyridines; Nitrile-triggered; Pd(II)-catalyst; 3-COMPONENT SYNTHESIS; CATALYZED ANNULATION; BETA-KETODINITRILES; ALKYNES; DISCOVERY; NITRILES; CONSTRUCTION; HETEROCYCLES; DERIVATIVES; POTENT;
D O I：
10.1002/chem.202403470
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Pd(II)-catalyzed non-template synthesis of furo[2,3-b]pyrrolo[2,3-d]pyridines from beta-ketodinitriles and buta-1,3-diynes has been accomplished via dual annulative cyclization. The participation of both the nitrile (-CN) groups led to the concurrent construction of three heterocycles viz. furan, pyrrole, and pyridine forming C-C, C=C, C-O, C-N, and C=N bonds in one pot. The synthetic utility of the protocol was further demonstrated through a few post-synthetic manipulations.
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页数：8
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