Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activation

被引：154

作者：

Zhong, Hongban ^{[1
]}

Yang, Dan ^{[1
]}

Wang, Songqing ^{[1
]}

Huang, Jianhui ^{[1
]}

机构：

[1] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 26期

关键词：

ATOM ECONOMY; O BOND; WEINREB AMIDES; CLEAVAGE; ALKYNES; BENZAMIDES; ANNULATION; MECHANISM; BASES; ACIDS;

D O I：

10.1039/c2cc17859a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described.

引用

页码：3236 / 3238

页数：3

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