Immune Playbook: Single-cell Analysis Reveals a Shift From Defensive Macrophage and NK to Offensive Memory and Cytotoxic T Cells in Lung Allograft Acute Cellular Rejection

被引:0
|
作者
Potter, A. [1 ]
Wikenheiser-Brokamp, K. A. [2 ]
Hildeman, D. [3 ]
Sharma, N. S. [4 ]
Gu, M. [5 ]
Patel, K. [6 ]
Qureshi, M. [7 ]
Khan, M. [8 ]
Wallace, C. [1 ]
Ziady, A. [9 ]
Hayes, D. [10 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Pulm Med, Cincinnati, OH USA
[2] Univ Cincinnati, Pathol & Lab Med, Cincinnati Childrens Hosp Med Ctr, Coll Med, Cincinnati, OH USA
[3] Cincinnati Childrens Hosp Med Ctr, Immunobiol, Cincinnati, OH USA
[4] Brigham & Womens Hosp, Boston, MA USA
[5] Cincinnati Childrens Hosp Med Ctr, Pediat, Cincinnati, OH USA
[6] Tampa Gen Hospital, Pulm & Crit Care, Morsani Coll Med, Tampa, FL USA
[7] Univ S Florida, Tampa, FL USA
[8] Brigham & Womens Hosp, Boston, MA USA
[9] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[10] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Cincinnati, OH USA
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A4398
引用
收藏
页数:2
相关论文
共 49 条
  • [41] Dual-Targeting Nanovesicles Carrying CSF1/CD47 Identified from Single-Cell Transcriptomics of Innate Immune Cells in Heart Transplant for Alleviating Acute Rejection
    Xu, Zhanxue
    Mao, Xiaofan
    Lu, Xingyu
    Shi, Peilin
    Ye, Jingping
    Yang, Xinrui
    Fu, Qingling
    He, Chao
    Su, Dandan
    Nie, Yichu
    Liu, Longshan
    Wang, Changxi
    Zhou, Benjie
    Luo, Wei
    Cheng, Fang
    Chen, Hongbo
    ADVANCED HEALTHCARE MATERIALS, 2024, 13 (07)
  • [42] Identification of an antigen-presenting cells/T/NK cells-related gene signature to predict prognosis and CTSL to predict immunotherapeutic response for lung adenocarcinoma: an integrated analysis of bulk and single-cell RNA sequencing
    Huang, Liling
    Lou, Ning
    Xie, Tongji
    Tang, Le
    Han, Xiaohong
    Shi, Yuankai
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023, 72 (10) : 3259 - 3277
  • [43] Identification of an antigen-presenting cells/T/NK cells-related gene signature to predict prognosis and CTSL to predict immunotherapeutic response for lung adenocarcinoma: an integrated analysis of bulk and single-cell RNA sequencing
    Liling Huang
    Ning Lou
    Tongji Xie
    Le Tang
    Xiaohong Han
    Yuankai Shi
    Cancer Immunology, Immunotherapy, 2023, 72 : 3259 - 3277
  • [44] Single-Cell Analysis Uncovers Striking Cellular Heterogeneity of Lung-Infiltrating fi ltrating Regulatory T Cells during Eosinophilic versus Neutrophilic Allergic Airway Inflammation fl ammation
    Iamsawat, Supinya
    Yu, Rongzhen
    Kim, Sohee
    Dvorina, Nina
    Qiu, Kevin
    Choi, Jaehyuk
    Baldwin, William M.
    Min, Booki
    JOURNAL OF IMMUNOLOGY, 2024, 212 (12): : 1867 - 1876
  • [45] Single-Cell Transcriptomic Profiling of T Cells from Blinatumomab-Treated Patients with BCell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Reveals Circulating CD8 T Cell Subsets Associated with Treatment Response
    Corrado, Francesco
    Wulf, Jan
    Straub, Tobias
    Nixdorf, Daniel
    Marcinek, Anetta
    Philipp, Nora
    Chu, Chang-Feng
    Zielinski, Christina
    von Bergwelt-Baildon, Michael
    Blumenberg, Viktoria
    Kazerani, Maryam
    Subklewe, Marion
    Buecklein, Veit L.
    BLOOD, 2023, 142
  • [46] Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy.
    Peters, A. L.
    Begum, G.
    Roskin, K.
    Woodle, E.
    Hildeman, D.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 615 - 616
  • [47] Identification and validation of a novel signature based on immune-related genes from epithelial cells to predict prognosis and treatment response in patients with lung squamous cell cancer by integrated analysis of single-cell and bulk RNA sequencing
    Wu, Jiajun
    Li, Zhifeng
    Zhou, Weijun
    Hu, Zhuozheng
    Gao, Kun
    Yang, Jin
    Zhang, Wenxiong
    ONCOLOGY LETTERS, 2025, 29 (03)
  • [48] Single cell spatial analysis of lungs from patients with fatal COVID-19 reveals a cellular network marked by inflammatory foci of immature neutrophil and CD8 T cells localised to alveolar progenitor cells
    Weeratunga, Praveen
    Denney, Laura
    Bull, Joshua
    Repapi, Emmanouela
    Sergeant, Martin
    Vuppusetty, Chaitanya
    Byrne, Helen
    Taylor, Stephen
    Ho, Ling-Pei
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62
  • [49] Single-Cell and TCR Analysis from Duchenne Muscular Dystrophy Patients Treated with AAV9 Mini-Dystrophin Reveals an Expansion of Human Herpesvirus-Specific T-Cells in a Patient That Exhibited Thrombotic Microangiopathy
    Emami, Micahel
    Brimble, Mark A.
    Espinoza, Alejandro
    Owens, Jane
    Lanz, Thomas A.
    Farahat, Philip K.
    Pellegrini, Matteo
    Young, Courtney
    Thomas, Paul G.
    Villalta, Armando
    Schattgen, Stefan A.
    Spencer, Melissa J.
    MOLECULAR THERAPY, 2024, 32 (04) : 235 - 236