Immune Playbook: Single-cell Analysis Reveals a Shift From Defensive Macrophage and NK to Offensive Memory and Cytotoxic T Cells in Lung Allograft Acute Cellular Rejection

被引：0
|
作者：
Potter, A. [1 ]
Wikenheiser-Brokamp, K. A. [2 ]
Hildeman, D. [3 ]
Sharma, N. S. [4 ]
Gu, M. [5 ]
Patel, K. [6 ]
Qureshi, M. [7 ]
Khan, M. [8 ]
Wallace, C. [1 ]
Ziady, A. [9 ]
Hayes, D. [10 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Pulm Med, Cincinnati, OH USA
[2] Univ Cincinnati, Pathol & Lab Med, Cincinnati Childrens Hosp Med Ctr, Coll Med, Cincinnati, OH USA
[3] Cincinnati Childrens Hosp Med Ctr, Immunobiol, Cincinnati, OH USA
[4] Brigham & Womens Hosp, Boston, MA USA
[5] Cincinnati Childrens Hosp Med Ctr, Pediat, Cincinnati, OH USA
[6] Tampa Gen Hospital, Pulm & Crit Care, Morsani Coll Med, Tampa, FL USA
[7] Univ S Florida, Tampa, FL USA
[8] Brigham & Womens Hosp, Boston, MA USA
[9] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[10] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Cincinnati, OH USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2024年 / 209卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A4398
引用
收藏
页数：2
相关论文
共 49 条
  • [31] Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response
    Levine, Lauren S.
    Hiam-Galvez, Kamir J.
    Marquez, Diana M.
    Tenvooren, Iliana
    Madden, Matthew Z.
    Contreras, Diana C.
    Dahunsi, Debolanle O.
    Irish, Jonathan M.
    Oluwole, Olalekan O.
    Rathmell, Jeffrey C.
    Spitzer, Matthew H.
    IMMUNITY, 2021, 54 (04) : 829 - +
  • [32] Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
    Wang, Yufei
    Li, Ronghong
    Tong, Renyang
    Chen, Taiwei
    Sun, Mingze
    Luo, Lingjie
    Li, Zheng
    Chen, Yifan
    Zhao, Yichao
    Zhang, Chensheng
    Wei, Lin
    Lin, Wei
    Chen, Haoyan
    Qian, Kun
    Chen, Alex F.
    Liu, Junling
    Chen, Lei
    Li, Bin
    Wang, Feng
    Wang, Li
    Su, Bing
    Pu, Jun
    NATURE IMMUNOLOGY, 2025, : 308 - 322
  • [33] Single cell tracking reveals the segregation of slow cycling memory CD8T cells from the effector pool at the peak of the immune response
    Kinjyo, I.
    Qin, J.
    Mrass, P.
    Wellard, C. J.
    Tomura, M.
    Kanagawa, O.
    Miyawaki, A.
    Hodgkin, P. D.
    Weninger, W.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 : S7 - S7
  • [34] Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4+ T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report
    Takeda, Shintaro
    Emoto, Takuo
    Yamashita, Tomoya
    Yamamoto, Hiroyuki
    Takaya, Tomofumi
    Sawada, Takahiro
    Yoshida, Takeshi
    Inoue, Masatoshi
    Suzuki, Yuya
    Hamana, Tomoyo
    Inoue, Taishi
    Taniguchi, Masayuki
    Sasaki, Naoto
    Otake, Hiromasa
    Ohkawa, Takenao
    Furuyashiki, Tomoyuki
    Kawai, Hiroya
    Hirata, Ken-ichi
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2024, 44 (05) : 1135 - 1143
  • [35] Gene-expression analysis of blood memory CD8+T cells at the single-cell level reveals a specific pattern of clonally expanded cells in multiple sclerosis patients
    Dugast, E.
    Vogel, I.
    Garcia, A.
    Nicol, B.
    Morille, J.
    Jacq-Foucher, M.
    Jousset, N.
    Le Frere, F.
    Wiertlewski, S.
    Tarte, K.
    Nicot, A.
    Michel, L.
    Berthelot, L.
    Gourraud, P. -A.
    Laplaud, D. -A.
    MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 192 - 192
  • [36] Single-cell TCR analysis of mouse lung Vγ4 γδT cells reveals a link between TCR clonotypes, SLAM family receptor expression, and effector function
    Mistri, Somen K.
    Hampel, Kenneth J.
    Sidoropoulos, Nikoletta
    Dienz, Oliver
    Boyson, Jonathan E.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [37] Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases
    Gao, Chao
    Wang, Shiguan
    Xie, Xiaoyu
    Ramadori, Pierluigi
    Li, Xinying
    Liu, Xiaoyu
    Ding, Xue
    Liang, Jinyuan
    Xu, Bowen
    Feng, Yawei
    Tan, Xueying
    Wang, Haoran
    Zhang, Yan
    Zhang, Haiyan
    Zhang, Tingguo
    Mi, Ping
    Li, Shiyang
    Zhang, Cuijuan
    Yuan, Detian
    Heikenwalder, Mathias
    Zhang, Peng
    CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2025, 19 (02):
  • [38] Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
    Tkachev, Victor
    Kaminski, James
    Potter, E. Lake
    Furlan, Scott N.
    Yu, Alison
    Hunt, Daniel J.
    McGuckin, Connor
    Zheng, Hengqi
    Colonna, Lucrezia
    Gerdemann, Ulrike
    Carlson, Judith
    Hoffman, Michelle
    Olvera, Joe
    English, Chris
    Baldessari, Audrey
    Panoskaltsis-Mortari, Angela
    Watkins, Benjamin
    Qayed, Muna
    Suessmuth, Yvonne
    Betz, Kayla
    Bratrude, Brandi
    Langston, Amelia
    Horan, John T.
    Ordovas-Montanes, Jose
    Shalek, Alex K.
    Blazar, Bruce R.
    Roederer, Mario
    Kean, Leslie S.
    SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (576)
  • [39] Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
    Sarah F. Rosen
    Allison L. Soung
    Wei Yang
    Shenjian Ai
    Marlene Kanmogne
    Veronica A. Davé
    Maxim Artyomov
    Jeffrey A. Magee
    Robyn S. Klein
    Genome Medicine, 14
  • [40] Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
    Rosen, Sarah F.
    Soung, Allison L.
    Yang, Wei
    Ai, Shenjian
    Kanmogne, Marlene
    Dave, Veronica A.
    Artyomov, Maxim
    Magee, Jeffrey A.
    Klein, Robyn S.
    GENOME MEDICINE, 2022, 14 (01)
12345