INTRAVESICAL MUC16 TARGETING CAR T CELLS FOR ORGAN-CONFINED BLADDER CANCERS

被引：0

作者：

Parwiz, Abrahimi ^{[1
]}

Jonathan, Khan ^{[1
]}

Alyssa, Duren-Lubanski ^{[1
]}

Winson, Cai ^{[1
]}

Yacine, Marouf ^{[1
]}

Jacob, Tallman ^{[1
]}

Bishoy, Faltas ^{[1
]}

Hikmat, Al Ahmadie ^{[1
]}

Olivier, Elemento ^{[1
]}

Benjamin, Hopkins ^{[1
]}

Douglas, Scherr ^{[1
]}

Renier, Brentjens ^{[1
]}

Jedd, Wolchok ^{[1
]}

Taha, Merghoub ^{[1
]}

机构：

[1] Weill Cornell Urol, New York, NY USA

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2025年 / 43卷 / 03期

关键词：

D O I：

10.1016/j.urolonc.2024.12.242

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

243

引用

页数：2

共 46 条

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[33] CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process
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[34] CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process
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[35] hYP218 CAR-T cells targeting a membrane-proximal epitope of mesothelin are highly effective against mesothelin expressing cancers.
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[36] Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers
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[37] CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer
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[38] A phase I clinical trial of autologous chimeric antigen receptor (CAR) T cells genetically engineered to secrete IL-12 and to target the MUC16ecto antigen in patients (pts) with MUC16ecto+recurrent high-grade serous ovarian cancer (HGSOC)
O'Cearbhaill, R. E.
Park, J. H.
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GYNECOLOGIC ONCOLOGY, 2020, 159 : 42 - 42
[39] Highly proliferative and hypodifferentiated CAR-T cells targeting B7-H3 enhance antitumor activity against ovarian and triple-negative breast cancers
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[40] Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
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CELLULAR IMMUNOLOGY, 2023, 391

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