Quasi-torpor for long-duration space missions

被引:0
|
作者
Weissman, Alexandra J. [1 ]
Flickinger, Katharyn L. [1 ]
Wu, Victor [1 ]
DeMaio, Ryann [1 ]
Jonsson, Andrea [2 ]
Prescott, Peter [3 ]
Monteleone, Jenna [1 ]
Zurowski, Emma [1 ]
Guyette, Francis Xavier [1 ]
Gordon, Benjamin D. H. [4 ]
Mortreux, Marie [5 ]
Melanson, Kathleen [5 ]
Buysse, Daniel J. [6 ]
Empey, Philip E. [7 ]
Callaway, Clifton W. [1 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Emergency Med, Pittsburgh, PA 15213 USA
[2] Philadelphia Coll Osteopath Med, Philadelphia, PA USA
[3] Oakland Univ, William Beaumont Sch Med, Auburn Hills, MI USA
[4] Univ Pittsburgh, Sch Educ, Dept Hlth & Human Dev, Pittsburgh, PA USA
[5] Univ Rhode Isl, Dept Nutr, Kingston, RI USA
[6] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
[7] Univ Pittsburgh, Ctr Clin Pharmaceut Sci, Dept Pharm & Therapeut, Sch Pharm, Pittsburgh, PA USA
来源
基金
美国国家航空航天局;
关键词
long-duration space travel; metabolism; exercise; sedation; cooling; ENERGY-EXPENDITURE; CIRCADIAN-RHYTHMS; METABOLIC SUPPRESSION; SLEEP; EXERCISE; TEMPERATURE; SPACEFLIGHT; PERFORMANCE; ASTRONAUTS; NUTRITION;
D O I
10.3389/frspt.2024.1457487
中图分类号
V [航空、航天];
学科分类号
08 ; 0825 ;
摘要
Innovative solutions are required to make long-duration space missions feasible. Crew performance and health is paramount to the success of anticipated Moon and Mars missions. Metabolic reduction via a quasi-torpor state is a possible mitigation strategy that can reduce consumable payload, which is necessary given the lack of available resupply options, and to reduce psychological stress, which is a risk for such lengthy missions. Even in lunar or cis-lunar missions, a quasi-torpor state could be implemented as an emergency countermeasure for critical situations where life support becomes limited. However, to date no studies have tested a quasi-torpor state in humans, and the impacts of intentional prolonged metabolic reduction on physiological and psychological parameters are unknown. To this end, we planned a three-phase study to provide proof-in-principle of the tolerability, feasibility, and side effects of a non-intravenous alpha-2-adrenergic receptor agonist for moderate sedation. This was accomplished by 1) determining the dosing and metabolic effects for different non-intravenous routes of alpha-2-adrenergic receptor agonist drugs; 2) assessing the degree of metabolic reduction and side effects during a 24-h quasi-torpor protocol; and 3) evaluating participant performance and total metabolic reduction achieved over a 5-day quasi-torpor protocol. We also aim to determine how skeletal muscle health and performance are affected by this quasi-torpor state. Quasi-torpor induced changes in skeletal muscle health and performance, as well as impacts on cognition and psychological stress, also have implications for terrestrial situations that result in prolonged confinement (e.g., austere environments such as submarine or remote scientific or military deployment and protracted critical illness). The findings of this three-phase study will be immediately applicable as a rescue strategy for emergencies during current or upcoming space missions. They will also identify key physiological and practical questions that need to be addressed for future deployment in long-duration space missions. This paper reviews the relevant literature that informed our rationale and approaches for this three-phase study.
引用
收藏
页数:12
相关论文
共 50 条
  • [31] Psychosocial issues affecting crews during long-duration international space missions
    Kanas, N
    ACTA ASTRONAUTICA, 1998, 42 (1-8) : 339 - 361
  • [32] Increased core body temperature in astronauts during long-duration space missions
    Alexander C. Stahn
    Andreas Werner
    Oliver Opatz
    Martina A. Maggioni
    Mathias Steinach
    Victoria Weller von Ahlefeld
    Alan Moore
    Brian E. Crucian
    Scott M. Smith
    Sara R. Zwart
    Thomas Schlabs
    Stefan Mendt
    Tobias Trippel
    Eberhard Koralewski
    Jochim Koch
    Alexander Choukèr
    Günther Reitz
    Peng Shang
    Lothar Röcker
    Karl A. Kirsch
    Hanns-Christian Gunga
    Scientific Reports, 7
  • [33] Serious Games for Team Training and Knowledge Retention for Long-Duration Space Missions
    Ramachandran, Sowmya
    Presnell, Bart
    Richards, Rob
    2016 IEEE AEROSPACE CONFERENCE, 2016,
  • [34] Protecting Astronauts from Infectious Disease During Long-duration Space Missions
    Frey, Mary Anne
    AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 2010, 81 (04): : 433 - 434
  • [35] Increased core body temperature in astronauts during long-duration space missions
    Stahn, Alexander C.
    Werner, Andreas
    Opatz, Oliver
    Maggioni, Martina A.
    Steinach, Mathias
    von Ahlefeld, Victoria Weller
    Moore, Alan
    Crucian, Brian E.
    Smith, Scott M.
    Zwart, Sara R.
    Schlabs, Thomas
    Mendt, Stefan
    Trippel, Tobias
    Koralewski, Eberhard
    Koch, Jochim
    Chouker, Alexander
    Reitz, Guenther
    Shang, Peng
    Roecker, Lothar
    Kirsch, Karl A.
    Gunga, Hanns-Christian
    SCIENTIFIC REPORTS, 2017, 7
  • [36] Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions
    Tesei, Donatella
    Jewczynko, Anna
    Lynch, Anne
    Urbaniak, Camilla
    LIFE-BASEL, 2022, 12 (04):
  • [37] Contingency Planning for Long-Duration AUV Missions
    Harris, Catherine
    Dearden, Richard
    2012 IEEE/OES AUTONOMOUS UNDERWATER VEHICLES (AUV), 2012,
  • [38] Considerations for development of countermeasures for physiological decrements associated with long-duration space missions
    Sawin, C. F.
    Hayes, J.
    Francisco, D. R.
    House, N.
    ACTA ASTRONAUTICA, 2007, 60 (4-7) : 488 - 496
  • [39] 3D Printing of Surgical Instruments for Long-Duration Space Missions
    Wong, Julielynn Y.
    Pfahnl, Andreas C.
    AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 2014, 85 (07): : 758 - 763
  • [40] Training for Long-Duration Space Missions: A Literature Review into Skill Retention and Generalizability
    Pieters, Marc A.
    Zaal, Peter M. T.
    IFAC PAPERSONLINE, 2019, 52 (19): : 247 - 252