Quasi-torpor for long-duration space missions

被引:0
|
作者
Weissman, Alexandra J. [1 ]
Flickinger, Katharyn L. [1 ]
Wu, Victor [1 ]
DeMaio, Ryann [1 ]
Jonsson, Andrea [2 ]
Prescott, Peter [3 ]
Monteleone, Jenna [1 ]
Zurowski, Emma [1 ]
Guyette, Francis Xavier [1 ]
Gordon, Benjamin D. H. [4 ]
Mortreux, Marie [5 ]
Melanson, Kathleen [5 ]
Buysse, Daniel J. [6 ]
Empey, Philip E. [7 ]
Callaway, Clifton W. [1 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Emergency Med, Pittsburgh, PA 15213 USA
[2] Philadelphia Coll Osteopath Med, Philadelphia, PA USA
[3] Oakland Univ, William Beaumont Sch Med, Auburn Hills, MI USA
[4] Univ Pittsburgh, Sch Educ, Dept Hlth & Human Dev, Pittsburgh, PA USA
[5] Univ Rhode Isl, Dept Nutr, Kingston, RI USA
[6] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
[7] Univ Pittsburgh, Ctr Clin Pharmaceut Sci, Dept Pharm & Therapeut, Sch Pharm, Pittsburgh, PA USA
来源
基金
美国国家航空航天局;
关键词
long-duration space travel; metabolism; exercise; sedation; cooling; ENERGY-EXPENDITURE; CIRCADIAN-RHYTHMS; METABOLIC SUPPRESSION; SLEEP; EXERCISE; TEMPERATURE; SPACEFLIGHT; PERFORMANCE; ASTRONAUTS; NUTRITION;
D O I
10.3389/frspt.2024.1457487
中图分类号
V [航空、航天];
学科分类号
08 ; 0825 ;
摘要
Innovative solutions are required to make long-duration space missions feasible. Crew performance and health is paramount to the success of anticipated Moon and Mars missions. Metabolic reduction via a quasi-torpor state is a possible mitigation strategy that can reduce consumable payload, which is necessary given the lack of available resupply options, and to reduce psychological stress, which is a risk for such lengthy missions. Even in lunar or cis-lunar missions, a quasi-torpor state could be implemented as an emergency countermeasure for critical situations where life support becomes limited. However, to date no studies have tested a quasi-torpor state in humans, and the impacts of intentional prolonged metabolic reduction on physiological and psychological parameters are unknown. To this end, we planned a three-phase study to provide proof-in-principle of the tolerability, feasibility, and side effects of a non-intravenous alpha-2-adrenergic receptor agonist for moderate sedation. This was accomplished by 1) determining the dosing and metabolic effects for different non-intravenous routes of alpha-2-adrenergic receptor agonist drugs; 2) assessing the degree of metabolic reduction and side effects during a 24-h quasi-torpor protocol; and 3) evaluating participant performance and total metabolic reduction achieved over a 5-day quasi-torpor protocol. We also aim to determine how skeletal muscle health and performance are affected by this quasi-torpor state. Quasi-torpor induced changes in skeletal muscle health and performance, as well as impacts on cognition and psychological stress, also have implications for terrestrial situations that result in prolonged confinement (e.g., austere environments such as submarine or remote scientific or military deployment and protracted critical illness). The findings of this three-phase study will be immediately applicable as a rescue strategy for emergencies during current or upcoming space missions. They will also identify key physiological and practical questions that need to be addressed for future deployment in long-duration space missions. This paper reviews the relevant literature that informed our rationale and approaches for this three-phase study.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] Lessons from a Space Analog on Adaptation for Long-Duration Exploration Missions
    Anglin, Katlin M.
    Kring, Jason P.
    AEROSPACE MEDICINE AND HUMAN PERFORMANCE, 2016, 87 (04) : 406 - 410
  • [22] Leadership for long-duration space missions: A shift toward a collective approach
    Mulhearn, Tyler
    McIntosh, Tristan
    Gibson, Carter
    Mumford, Michael D.
    Yammarino, Francis J.
    Connelly, Shane
    Day, Eric Anthony
    Vessey, Brandon
    ACTA ASTRONAUTICA, 2016, 129 : 466 - 476
  • [23] Studies of the Activity of the Central Respiratory Mechanism in Long-Duration Space Missions
    Baranov V.M.
    Katuntsev V.P.
    Tarasenkov G.G.
    Khudiakova E.P.
    Sedelkova V.A.
    Alferova I.V.
    Shushunova T.G.
    Human Physiology, 2023, 49 (7) : 780 - 786
  • [24] The Challenge of Maintaining a Healthy Microbiome during Long-Duration Space Missions
    Voorhies, Alexander A.
    Lorenzi, Hernan A.
    FRONTIERS IN ASTRONOMY AND SPACE SCIENCES, 2016, 3
  • [25] Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
    Voorhies, Alexander A.
    Ott, C. Mark
    Mehta, Satish
    Pierson, Duane L.
    Crucian, Brian E.
    Feiveson, Alan
    Oubre, Cherie M.
    Torralba, Manolito
    Moncera, Kelvin
    Zhang, Yun
    Zurek, Eduardo
    Lorenzi, Hernan A.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [26] Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
    Alexander A. Voorhies
    C. Mark Ott
    Satish Mehta
    Duane L. Pierson
    Brian E. Crucian
    Alan Feiveson
    Cherie M. Oubre
    Manolito Torralba
    Kelvin Moncera
    Yun Zhang
    Eduardo Zurek
    Hernan A. Lorenzi
    Scientific Reports, 9
  • [27] Psychosocial issues affecting crews during long-duration international space missions
    Kanas, Nick
    Acta Astronautica, 42 (1-8): : 339 - 361
  • [28] Advanced biosensors for monitoring astronauts' health during long-duration space missions
    Roda, Aldo
    Mirasoli, Mara
    Guardigli, Massimo
    Zangheri, Martina
    Caliceti, Cristiana
    Calabria, Donato
    Simoni, Patrizia
    BIOSENSORS & BIOELECTRONICS, 2018, 111 : 18 - 26
  • [29] Thoracolumbar spine muscle size and composition changes in long-duration space missions
    Poveda, Luis
    Dash, Siddharth
    Madrid, Diana
    Devane, Karan
    Lenchik, Leon
    Tooze, Janet
    Weaver, Ashley A.
    LIFE SCIENCES IN SPACE RESEARCH, 2025, 44 : 1 - 8
  • [30] IMMUNE CHANGES DURING LONG-DURATION MISSIONS
    KONSTANTINOVA, IV
    RYKOVA, MP
    LESNYAK, AT
    ANTROPOVA, EA
    JOURNAL OF LEUKOCYTE BIOLOGY, 1993, 54 (03) : 189 - 201