Continued Directed Evolution of VCAP-101 and VCAP-102 Identifies Second Generation Capsid Variants with Increased Brain Tropism and in Non-Human Primates and Mice

被引：0

作者：

Moyer, Tyler ^{[1
]}

Graham, Kristin ^{[1
]}

Liu, Jiachen ^{[1
]}

Ren, Xiaoqin ^{[1
]}

Clement, Joseph ^{[1
]}

Bloedel, Alexis ^{[1
]}

Spellman, Rebecca ^{[1
]}

Arce, Camila ^{[1
]}

Khalid, Hamza ^{[1
]}

Kulkarni, Anupriya ^{[1
]}

Tsolias, Alexandra ^{[1
]}

Zhao, Rong ^{[1
]}

Yang, Wenya ^{[1
]}

Bruce, Amy ^{[1
]}

Egbuchulam, Chiso ^{[1
]}

Knox, Tatianna ^{[1
]}

Hoffman, Brett ^{[1
]}

Shah, Ishan ^{[1
]}

Grannan, Michael ^{[1
]}

Chung, Charlotte ^{[1
]}

Kutchin, Alexander ^{[1
]}

Amy, Johnson ^{[1
]}

Grant, Kyle ^{[1
]}

Pande, Nilesh ^{[1
]}

Thompson, Jeff ^{[1
]}

Yao, Johnny ^{[1
]}

Sadhu, Chanchal ^{[1
]}

Carter, Todd A. ^{[1
]}

Nonnenmacher, Mathieu E. ^{[1
]}

机构：

[1] Voyager Therapeut, Cambridge, MA USA

来源：

MOLECULAR THERAPY | 2024年 / 32卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

119.

引用

页码：64 / 65

页数：2

共 8 条

[1] Directed Evolution of an AAV9 Library Identifies a Capsid Variant with Enhanced Brain Tropism and Liver De-Targeting in Non-Human Primates and Mice Following Systemic Administration
Moyer, Tyler
Graham, Kristin
Liu, Jiachen
Ren, Xiaoqin
Clement, Joseph
Bloedel, Alexis
Kulkarni, Anupriya
Looby, Kailyn
Khalid, Hamza
Amy, Bruce
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Laks, Dan
Child, Matthew
Kaur, Rupinderjit
Sayed-Zahid, Ambreen
Grannan, Michael
Chung, Charlotte
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Hoffman, Brett
Kutchin, Alex
Johnson, Amy
Cameron, Andrew
Grant, Kyle
Yao, Johnny
Pande, Nilesh
Thompson, Jeff
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MOLECULAR THERAPY, 2023, 31 (04) : 57 - 57
[2] Directed Evolution of AAV9 Peptide Display Libraries Identifies a Family of Cross-Species Variants with Enhanced Brain Tropism in Non-Human Primates and Mice Following Systemic Administration
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Li, Jiangyu
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[3] Identification of a cell surface receptor utilized by an engineered BBB-penetrant capsid family with enhanced brain tropism in non-human primates and mice
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[4] Directed Evolution of AAV9 Libraries in Non-Human Primates Identifies a Capsid Family with Enhanced Central Nervous System Tropism and Liver De-Targeting Following Systemic Delivery
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[5] Directed Evolution of Novel MyoAAV Capsid Variants Enabling Effective Systemic Muscle Transduction While De-Targeting the Liver in Non-Human Primates
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Wang, Wei
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[7] Directed Evolution of AAV Targeting Lung Epithelia Using Aerosol Delivery Identifies 4D-A101, a Variant Demonstrating Robust Gene Delivery in Non-Human Primates
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[8] Cell Type-Specific TRAnscription-Dependent Directed Evolution (TRADE) Identifies Novel AAV Capsids Capable of Enhanced Neuronal Transduction in Mice and Non-Human Primates
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