Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer

被引：0
|
作者：
Yupeng Jiang [1 ]
Yuyao Liu [2 ]
Hong Huang [3 ]
Tiantian Zhao [1 ]
Zengyi Zhao [1 ]
Yawen Gao [1 ]
机构：
[1] The Second Xiangya Hospital,Department of Oncology
[2] Central South University,Department of Oncology
[3] The Affiliated Changsha Central Hospital,undefined
[4] Hengyang Medical School,undefined
[5] University of South China,undefined
[6] Guilin Medical University,undefined
来源：
Cancer Immunology, Immunotherapy | / 74卷 / 3期
关键词：
RAS mutation; High microsatellite instability; Deficient mismatch repair; Colorectal cancer; Tumor microenvironment;
D O I：
10.1007/s00262-024-03926-9
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities
    Zhang, Xuan
    Wu, Tao
    Cai, Xinyi
    Dong, Jianhua
    Xia, Cuifeng
    Zhou, Yongchun
    Ding, Rong
    Yang, Renfang
    Tan, Jing
    Zhang, Lijuan
    Zhang, Ya
    Wang, Yuqin
    Dong, Chao
    Li, Yunfeng
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [32] Clinical outcomes of immune checkpoint inhibitor (ICI) therapy among Veterans Affairs patients with colorectal cancer and discordant dMMR/MSI-H status.
    Isaacs, James
    Guo, Aixia
    Vashistha, Vishal
    Katsoulakis, Evangelia
    Boswell, Elizabeth
    Strickler, John H.
    Ahmed, Sara
    Kelley, Michael J.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [33] Real-world experience of immune checkpoint inhibitors in MSI-H/dMMR metastatic colorectal cancer in a tertiary cancer center in Saudi Arabia
    Ajina, R.
    Alhareeri, A.
    Philip, W.
    Alsekait, N.
    Alarifi, N.
    Alismail, H.
    Alshieban, S.
    Almuzzaini, B.
    Alshammari, K.
    ANNALS OF ONCOLOGY, 2023, 34 : S117 - S117
  • [34] Prevalence and Associations of Beta2-Microglobulin Mutations in MSI-H/dMMR Cancers
    Liu, Fangcen
    Zhong, Fangfang
    Wu, Huan
    Che, Keying
    Shi, Jiaochun
    Wu, Nandie
    Fu, Yao
    Wang, Yue
    Hu, Jing
    Qian, Xiaoping
    Fan, Xiangshan
    Wang, Weifeng
    Wei, Jia
    ONCOLOGIST, 2023, : e136 - e144
  • [35] COMPANION DIAGNOSTIC ASSAYS FOR PEMBROLIZUMAB IN PATIENTS WITH MSI-H/DMMR TUMORS
    Marabelle, Aurelien
    Cesario, Jeff
    Lang, Lixin
    Aurora-Garg, Deepti
    Mathur, Siddhartha Krishan
    Levitan, Diane
    Card, Deb
    Jin, Fan
    Adelberg, David
    Andre, Thierry
    Wehn, Amy
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A569 - A569
  • [36] Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience
    Higbie, Victoria Serpas
    Rogers, Jane
    Hwang, Hyunsoo
    Qiao, Wei
    Xiao, Lianchun
    Dasari, Arvind
    Mola-Rudd, Kerri
    Morris, Van K.
    Wolff, Robert A.
    Raghav, Kanwal
    Huey, Ryan
    Parseghian, Christine
    Willis, Jason
    Kopetz, Scott
    Overman, Michael J.
    Johnson, Benny
    ONCOLOGIST, 2022, 27 (11): : 952 - 957
  • [37] Natural history and patterns of progression for dMMR/MSI-H colorectal cancer treated with immune checkpoint blockade: A single center retrospective analysis.
    Higbie, Victoria
    Shah, Preksha
    Bent, Alisha Heather
    Dasari, Arvind
    Huey, Ryan W.
    Johnson, Benny
    Kee, Bryan K.
    Kopetz, Scott
    Lee, Michael Sangmin
    Ludford, Kaysia
    Morelli, Maria Pia
    Morris, Van K.
    Parseghian, Christine Megerdichian
    Raghav, Kanwal Pratap Singh
    Shen, John Paul Y. C.
    Willis, Jason
    Wolff, Robert A.
    Overman, Michael J.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 145 - 145
  • [38] The controversial abscopal effect: A single-center experience about the combination of stereotactic radiotherapy with pembrolizumab in patients with metastatic dMMR/MSI-H colorectal cancer
    Gandini, Annalice
    Martelli, Valentino
    Belgioia, Liliana
    Puglisi, Silvia
    Cremante, Malvina
    Murianni, Veronica
    Damassi, Alessandra
    Ricciotti, Ilaria
    Pirrone, Chiara
    Catalano, Fabio
    Grassi, Massimiliano
    Pessino, Anna Maria
    Pastorino, Alessandro
    Sciallero, Stefania
    Puccini, Alberto
    Sobrero, Alberto F.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [39] Treatments after Immune Checkpoint Inhibitors in Patients with dMMR/MSI Metastatic Colorectal Cancer
    Bui, Quang Loc
    Mas, Leo
    Hollebecque, Antoine
    Tougeron, David
    de la Fouchardiere, Christelle
    Pudlarz, Thomas
    Alouani, Emily
    Guimbaud, Rosine
    Taieb, Julien
    Andre, Thierry
    Colle, Raphael
    Cohen, Romain
    CANCERS, 2022, 14 (02)
  • [40] Real-world treatment patterns and unmet need in patients with previously treated metastatic colorectal cancer that is not MSI-H or dMMR.
    Desai, Kaushal
    Sura, Sneha
    Liu, Zhimei
    Amonkar, Mayur
    Jain, Rishi
    Niehoff, Nicole
    Wilson, Thomas W.
    Patton, Gregory A.
    Cosgrove, David
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 53 - 53
12345